TY - JOUR
T1 - Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon
AU - Khan, Faisel
AU - Litchfield, Stuart J.
AU - McLaren, Margaret
AU - Veale, Douglas J.
AU - Littleford, Roberta C.
AU - Belch, Jill J. F.
PY - 1997/2
Y1 - 1997/2
N2 - Objective. To assess the effects of oral L-arginine supplementation on cutaneous vascular responses in patients with primary Raynaud's phenomenon (RP).
Methods. Double-blind, crossover comparison of placebo versus L-arginine (8 gm/day for 28 days), Cutaneous vascular responses in the fingers were assessed during iontophoresis of acetylcholine and sodium nitroprusside, which are endothelium-dependent and endothelium-independent vasodilators,
Results. In comparison with control subjects, patients with primary RP had diminished endothelium-dependent and -independent vasodilatation (P <0.05, and P <0.005, respectively, by analysis of variance), At the 3 doses used, vascular responses to acetylcholine were reduced by 71%, 64%, and 63%, respectively, and responses to sodium nitroprusside were reduced by 67%, 73%, and 66%, respectively, L-arginine had no significant effect on cutaneous vascular responses to acetylcholine or sodium nitroprusside in control subjects or patients with primary RP.
Conclusion. Reduced vasodilator ability in primary RP is unlikely to be due to an impairment in the L-arginine/nitric oxide pathway.
AB - Objective. To assess the effects of oral L-arginine supplementation on cutaneous vascular responses in patients with primary Raynaud's phenomenon (RP).
Methods. Double-blind, crossover comparison of placebo versus L-arginine (8 gm/day for 28 days), Cutaneous vascular responses in the fingers were assessed during iontophoresis of acetylcholine and sodium nitroprusside, which are endothelium-dependent and endothelium-independent vasodilators,
Results. In comparison with control subjects, patients with primary RP had diminished endothelium-dependent and -independent vasodilatation (P <0.05, and P <0.005, respectively, by analysis of variance), At the 3 doses used, vascular responses to acetylcholine were reduced by 71%, 64%, and 63%, respectively, and responses to sodium nitroprusside were reduced by 67%, 73%, and 66%, respectively, L-arginine had no significant effect on cutaneous vascular responses to acetylcholine or sodium nitroprusside in control subjects or patients with primary RP.
Conclusion. Reduced vasodilator ability in primary RP is unlikely to be due to an impairment in the L-arginine/nitric oxide pathway.
KW - NITRIC-OXIDE
KW - INHIBITS PLATELET-AGGREGATION
KW - DISEASE
U2 - 10.1002/art.1780400220
DO - 10.1002/art.1780400220
M3 - Article
SN - 0004-3591
VL - 40
SP - 352
EP - 357
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 2
ER -