Oscillometry defined small airways dysfunction as a treatable trait in asthma

Marcello Cottini, Carlo Lombardi, Pasquale Comberiati, Alvise Berti, Francesco Menzella, Ronald J. Dandurand, Zuzana Diamant, Rory Chan (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.

Original languageEnglish
JournalAnnals of Allergy, Asthma and Immunology
Early online date14 Nov 2024
DOIs
Publication statusE-pub ahead of print - 14 Nov 2024

Keywords

  • asthma
  • oscillometry
  • personalized treatment
  • small airways
  • treatable trait

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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