TY - JOUR
T1 - Oscillometry defined small airways dysfunction as a treatable trait in asthma
AU - Cottini, Marcello
AU - Lombardi, Carlo
AU - Comberiati, Pasquale
AU - Berti, Alvise
AU - Menzella, Francesco
AU - Dandurand, Ronald J.
AU - Diamant, Zuzana
AU - Chan, Rory
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/11/14
Y1 - 2024/11/14
N2 - The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.
AB - The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.
KW - asthma
KW - oscillometry
KW - personalized treatment
KW - small airways
KW - treatable trait
UR - http://www.scopus.com/inward/record.url?scp=85210085800&partnerID=8YFLogxK
U2 - 10.1016/j.anai.2024.11.006
DO - 10.1016/j.anai.2024.11.006
M3 - Review article
C2 - 39549987
SN - 1081-1206
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
ER -