Oscillometry defined small airways dysfunction as a treatable trait in asthma

Marcello Cottini; Carlo Lombardi; Pasquale Comberiati; Alvise Berti; Francesco Menzella; Ronald J. Dandurand; Zuzana Diamant; Rory Chan

doi:10.1016/j.anai.2024.11.006

Oscillometry defined small airways dysfunction as a treatable trait in asthma

Marcello Cottini
, Carlo Lombardi
, Pasquale Comberiati
, Alvise Berti
, Francesco Menzella
, Ronald J. Dandurand
, Zuzana Diamant
, Rory Chan (Lead / Corresponding author)

Respiratory Medicine and Gastroenterology

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

17 Downloads (Pure)

Abstract

The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.

Original language	English
Pages (from-to)	151-158
Journal	Annals of Allergy, Asthma and Immunology
Volume	134
Issue number	2
Early online date	14 Nov 2024
DOIs	https://doi.org/10.1016/j.anai.2024.11.006
Publication status	Published - Feb 2025

Keywords

asthma
oscillometry
personalized treatment
small airways
treatable trait

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine

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10.1016/j.anai.2024.11.006Licence: CC BY-NC-ND

Final published version
©2024 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Final published version, 1.22 MBLicence: CC BY-NC-ND

Cite this

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title = "Oscillometry defined small airways dysfunction as a treatable trait in asthma",

abstract = "The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.",

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AU - Cottini, Marcello

AU - Lombardi, Carlo

AU - Comberiati, Pasquale

AU - Berti, Alvise

AU - Menzella, Francesco

AU - Dandurand, Ronald J.

AU - Diamant, Zuzana

AU - Chan, Rory

PY - 2025/2

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N2 - The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.

AB - The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called “treatable traits” has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.

KW - asthma

KW - oscillometry

KW - personalized treatment

KW - small airways

KW - treatable trait

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SN - 1081-1206

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JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

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ER -

Oscillometry defined small airways dysfunction as a treatable trait in asthma

Abstract

Keywords

ASJC Scopus subject areas

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