TY - JOUR
T1 - Osteoimmunology
T2 - The effect of autoimmunity on fracture healing and skeletal analysis
AU - Lončar, Stephie R.
AU - Halcrow, Siân E.
AU - Swales, Diana
N1 - Funding Information:
Stephie R. Lončar was partially supported by the Inspire Foundation Marlborough, New Zealand and University of Dundee, Scotland, United Kingdom . We thank Professor Fordyce Davidson for his guidance with the mathematical models.
Copyright:
© 2023 The Authors.
PY - 2023
Y1 - 2023
N2 - Understanding factors that affect bone response to trauma is integral to forensic skeletal analysis. It is essential in forensic anthropology to identify if impaired fracture healing impacts assessment of post-traumatic time intervals and whether a correction factor is required. This paper presents a synthetic review of the intersection of the literature on the immune system, bone biology, and osteoimmunological research to present a novel model of interactions that may affect fracture healing under autoimmune conditions. Results suggest that autoimmunity likely impacts fracture healing, the pathogenesis however, is under researched, but likely multifactorial. With autoimmune diseases being relatively common, significant clinical history should be incorporated when assessing skeletal remains. Future research includes the true natural healing rate of bone; effect of autoimmunity on this rate; variation of healing with different autoimmune diseases; and if necessary, development of a correction factor on the natural healing rate to account for impairment in autoimmunity.
AB - Understanding factors that affect bone response to trauma is integral to forensic skeletal analysis. It is essential in forensic anthropology to identify if impaired fracture healing impacts assessment of post-traumatic time intervals and whether a correction factor is required. This paper presents a synthetic review of the intersection of the literature on the immune system, bone biology, and osteoimmunological research to present a novel model of interactions that may affect fracture healing under autoimmune conditions. Results suggest that autoimmunity likely impacts fracture healing, the pathogenesis however, is under researched, but likely multifactorial. With autoimmune diseases being relatively common, significant clinical history should be incorporated when assessing skeletal remains. Future research includes the true natural healing rate of bone; effect of autoimmunity on this rate; variation of healing with different autoimmune diseases; and if necessary, development of a correction factor on the natural healing rate to account for impairment in autoimmunity.
KW - Autoimmunity
KW - Forensic anthropology
KW - Fracture healing
KW - Osteoimmunology
KW - Post-traumatic time interval
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85151536403&partnerID=8YFLogxK
U2 - 10.1016/j.fsisyn.2023.100326
DO - 10.1016/j.fsisyn.2023.100326
M3 - Review article
C2 - 37091290
AN - SCOPUS:85151536403
SN - 2589-871X
VL - 6
JO - Forensic Science International: Synergy
JF - Forensic Science International: Synergy
M1 - 100326
ER -