Outcomes following endovascular therapy for acute stroke by interventional cardiologists

Tamunoinemi Bob-Manuel (Lead / Corresponding author), Marius Hornung, Steven Guidera, Marloe Prince, Antonio Duran, Horst Sievert, Stefan Bertog, Iris Grunwald, Christopher J. White

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To summarize the outcomes of acute ischemic stroke (AIS) intervention by interventional cardiologists (IC) working on a stroke team. Background: There is a geographic maldistribution of dedicated neuro-interventionalists (NI) to treat large vessel occlusion (LVO) AIS.

Methods: Results of 166 consecutive patients who received endovascular therapy (EVT) for AIS due to LVO by IC at three centers between 2009 and 2019 are reported. A modified Rankin score (mRs) of ≤ 2 at 90 days after EVT was used as the primary measurement of a good neurological outcome. Univariate logistic regression was used to evaluate predictors of the mRS > 2 and mortality. Those variables with significance of p <.2 from the univariate analysis were included in a multivariate analysis.

Results: All-cause mortality at 30 days was 22%. A favorable clinical outcome, mRS ≤ 2 at 90 days, was 49%. After multivariate analysis and controlling for confounders, a higher baseline NIHSS was predictive of 30-day mortality (OR 1.20 [95% CI 1.09–1.32] p <.001) and unfavorable clinical outcome (mRS > 2) at 90 days (OR 1.16 [95% CI 1.07–1.25] p <.001).

Conclusion: Outcomes for carotid stent capable IC performing EVT for AIS are comparable to those achieved by NI physicians in major randomized clinical trials. Our data supports conducting a clinical trial of carotid stent capable IC working on multidisciplinary stroke teams to perform EVT for AIS due to LVO in communities and hospitals without timely access (<60 min by ground transport) to dedicated NI.

Original languageEnglish
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Early online date20 Aug 2020
DOIs
Publication statusE-pub ahead of print - 20 Aug 2020

Keywords

  • endovascular therapy
  • geographic disparity
  • neuro-intervention

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