Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts

Stephen M Keyse, Lee Ann Applegate, Yvonne Tromvoukis, Rex M Tyrrell

    Research output: Contribution to journalArticle

    187 Citations (Scopus)

    Abstract

    Treatment of cultured human skin fibroblasts with near-UV radiation, hydrogen peroxide, and sodium arsenite induces accumulation of heme oxygenase mRNA and protein. In this study, these treatments led to a dramatic increase in the rate of RNA transcription from the heme oxygenase gene but had no effect on mRNA stability. Transcriptional activation, therefore, appears to be the major mechanism of stimulation of expression of this gene by either oxidative stress or sulfydryl reagents.
    Original languageEnglish
    Pages (from-to)4967-9
    Number of pages3
    JournalMolecular and Cellular Biology
    Volume10
    Issue number9
    DOIs
    Publication statusPublished - 1990

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