Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?

M. Chopra; J. McMurray; J. McLay; A. Bridges; N. Scott; W. E. Smith; J. J. F. Belch

doi:10.1007/978-1-4684-5730-8_40

Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?

M. Chopra, J. McMurray, J. McLay, A. Bridges, N. Scott, W. E. Smith, J. J. F. Belch

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

Abstract

The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.

Original language	English
Title of host publication	Antioxidants in Therapy and Preventive Medicine
Editors	Ingrid Emerit , Lester Packer, Christian Auclair
Publisher	Springer
Pages	251-255
Number of pages	5
ISBN (Electronic)	9781468457308
ISBN (Print)	9781468457322
DOIs	https://doi.org/10.1007/978-1-4684-5730-8_40
Publication status	Published - 1990

Publication series

Name	Advances in experimental medicine and biology
Publisher	Springer
Volume	264
ISSN (Print)	0065-2598

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10.1007/978-1-4684-5730-8_40

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Chopra, M., McMurray, J., McLay, J., Bridges, A., Scott, N., Smith, W. E., & Belch, J. J. F. (1990). Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging? In I. Emerit , L. Packer, & C. Auclair (Eds.), Antioxidants in Therapy and Preventive Medicine (pp. 251-255). (Advances in experimental medicine and biology; Vol. 264). Springer . https://doi.org/10.1007/978-1-4684-5730-8_40

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title = "Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?",

abstract = "The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.",

author = "M. Chopra and J. McMurray and J. McLay and A. Bridges and N. Scott and Smith, {W. E.} and Belch, {J. J. F.}",

year = "1990",

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language = "English",

isbn = "9781468457322",

series = "Advances in experimental medicine and biology",

publisher = "Springer ",

pages = "251--255",

editor = "{Emerit }, {Ingrid } and Packer, {Lester } and Auclair, {Christian }",

booktitle = "Antioxidants in Therapy and Preventive Medicine",

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Chopra, M, McMurray, J, McLay, J, Bridges, A, Scott, N, Smith, WE & Belch, JJF 1990, Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging? in I Emerit , L Packer & C Auclair (eds), Antioxidants in Therapy and Preventive Medicine. Advances in experimental medicine and biology, vol. 264, Springer , pp. 251-255. https://doi.org/10.1007/978-1-4684-5730-8_40

Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging? / Chopra, M.; McMurray, J.; McLay, J. et al.
Antioxidants in Therapy and Preventive Medicine. ed. / Ingrid Emerit ; Lester Packer; Christian Auclair. Springer , 1990. p. 251-255 (Advances in experimental medicine and biology; Vol. 264).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Oxidative damage in chronic heart failure

T2 - protection by captopril through free radical scavenging?

AU - Chopra, M.

AU - McMurray, J.

AU - McLay, J.

AU - Bridges, A.

AU - Scott, N.

AU - Smith, W. E.

AU - Belch, J. J. F.

PY - 1990

Y1 - 1990

N2 - The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.

AB - The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.

U2 - 10.1007/978-1-4684-5730-8_40

DO - 10.1007/978-1-4684-5730-8_40

M3 - Chapter

C2 - 2244503

SN - 9781468457322

T3 - Advances in experimental medicine and biology

SP - 251

EP - 255

BT - Antioxidants in Therapy and Preventive Medicine

A2 - Emerit , Ingrid

A2 - Packer, Lester

A2 - Auclair, Christian

PB - Springer

ER -

Chopra M, McMurray J, McLay J, Bridges A, Scott N, Smith WE et al. Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging? In Emerit I, Packer L, Auclair C, editors, Antioxidants in Therapy and Preventive Medicine. Springer . 1990. p. 251-255. (Advances in experimental medicine and biology). doi: 10.1007/978-1-4684-5730-8_40

Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?

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