Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?

M. Chopra, J. McMurray, J. McLay, A. Bridges, N. Scott, W. E. Smith, J. J. F. Belch

    Research output: Chapter in Book/Report/Conference proceedingChapter

    8 Citations (Scopus)

    Abstract

    The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.
    Original languageEnglish
    Title of host publicationAntioxidants in Therapy and Preventive Medicine
    EditorsIngrid Emerit , Lester Packer, Christian Auclair
    PublisherSpringer
    Pages251-255
    Number of pages5
    ISBN (Electronic)9781468457308
    ISBN (Print)9781468457322
    DOIs
    Publication statusPublished - 1990

    Publication series

    NameAdvances in experimental medicine and biology
    PublisherSpringer
    Volume264
    ISSN (Print)0065-2598

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