Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Andrey S. Marchev, Petya A. Dimitrova, Andrew J. Burns, Rumen Kostov, Albena Dinkova-Kostova, Milen I. Georgiev (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)
414 Downloads (Pure)

Abstract

Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity and disability. The disease starts with cartilage damage but then progressively involves subchondral bone causing an imbalance between osteoclast-driven bone resorption and osteoblasts-driven remodeling. Herein we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as, their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor-erythroid p45-related factor 2 (Nrf2), and we describe the regulation of Nrf2, highlighting its role in OA pathology. The beneficial effect of some phytonutrients, including the therapeutic potential of Nrf2 activation, in OA is also discussed.
Original languageEnglish
Pages (from-to)114-135
Number of pages22
JournalAnnals of the New York Academy of Sciences
Volume1401
Early online date29 Jun 2017
DOIs
Publication statusPublished - 11 Sep 2017

Keywords

  • Osteoarthritis
  • Nrf2
  • ROS
  • inflammation
  • phytochemicals

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