Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Andrey S. Marchev; Petya A. Dimitrova; Andrew J.  Burns; Rumen Kostov; Albena Dinkova-Kostova; Milen I. Georgiev

doi:10.1111/nyas.13407

Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Andrey S. Marchev, Petya A. Dimitrova, Andrew J. Burns, Rumen Kostov, Albena Dinkova-Kostova, Milen I. Georgiev (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

182 Citations (Scopus)

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Abstract

Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity and disability. The disease starts with cartilage damage but then progressively involves subchondral bone causing an imbalance between osteoclast-driven bone resorption and osteoblasts-driven remodeling. Herein we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as, their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor-erythroid p45-related factor 2 (Nrf2), and we describe the regulation of Nrf2, highlighting its role in OA pathology. The beneficial effect of some phytonutrients, including the therapeutic potential of Nrf2 activation, in OA is also discussed.

Original language	English
Pages (from-to)	114-135
Number of pages	22
Journal	Annals of the New York Academy of Sciences
Volume	1401
Early online date	29 Jun 2017
DOIs	https://doi.org/10.1111/nyas.13407
Publication status	Published - 11 Sept 2017

Keywords

Osteoarthritis
Nrf2
ROS
inflammation
phytochemicals

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/nyas.13407

Author Accepted ManuscriptAccepted author manuscript, 944 KB

The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)
Dinkova-Kostova, A. (Investigator)
Biotechnology and Biological Sciences Research Council
30/09/14 → 27/02/18
Project: Research

Cite this

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title = "Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?",

abstract = "Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity and disability. The disease starts with cartilage damage but then progressively involves subchondral bone causing an imbalance between osteoclast-driven bone resorption and osteoblasts-driven remodeling. Herein we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as, their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor-erythroid p45-related factor 2 (Nrf2), and we describe the regulation of Nrf2, highlighting its role in OA pathology. The beneficial effect of some phytonutrients, including the therapeutic potential of Nrf2 activation, in OA is also discussed.",

keywords = "Osteoarthritis, Nrf2, ROS, inflammation, phytochemicals",

author = "Marchev, {Andrey S.} and Dimitrova, {Petya A.} and Burns, {Andrew J.} and Rumen Kostov and Albena Dinkova-Kostova and Georgiev, {Milen I.}",

note = "Authors are thankful to the support received from the National Science Fund of Bulgaria (contract number DFNI B02/14) and Cancer Research UK (C20953/A18644), and the BBSRC (BB/L01923X/1).",

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month = sep,

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doi = "10.1111/nyas.13407",

language = "English",

volume = "1401",

pages = "114--135",

journal = "Annals of the New York Academy of Sciences",

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TY - JOUR

T1 - Oxidative stress and chronic inflammation in osteoarthritis

T2 - can Nrf2 counteract these partners in crime?

AU - Marchev, Andrey S.

AU - Dimitrova, Petya A.

AU - Burns, Andrew J.

AU - Kostov, Rumen

AU - Dinkova-Kostova, Albena

AU - Georgiev, Milen I.

N1 - Authors are thankful to the support received from the National Science Fund of Bulgaria (contract number DFNI B02/14) and Cancer Research UK (C20953/A18644), and the BBSRC (BB/L01923X/1).

PY - 2017/9/11

Y1 - 2017/9/11

N2 - Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity and disability. The disease starts with cartilage damage but then progressively involves subchondral bone causing an imbalance between osteoclast-driven bone resorption and osteoblasts-driven remodeling. Herein we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as, their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor-erythroid p45-related factor 2 (Nrf2), and we describe the regulation of Nrf2, highlighting its role in OA pathology. The beneficial effect of some phytonutrients, including the therapeutic potential of Nrf2 activation, in OA is also discussed.

AB - Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity and disability. The disease starts with cartilage damage but then progressively involves subchondral bone causing an imbalance between osteoclast-driven bone resorption and osteoblasts-driven remodeling. Herein we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as, their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor-erythroid p45-related factor 2 (Nrf2), and we describe the regulation of Nrf2, highlighting its role in OA pathology. The beneficial effect of some phytonutrients, including the therapeutic potential of Nrf2 activation, in OA is also discussed.

KW - Osteoarthritis

KW - Nrf2

KW - ROS

KW - inflammation

KW - phytochemicals

U2 - 10.1111/nyas.13407

DO - 10.1111/nyas.13407

M3 - Review article

C2 - 28662306

AN - SCOPUS:85021456651

SN - 0077-8923

VL - 1401

SP - 114

EP - 135

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Abstract

Keywords

UN SDGs

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Projects

The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

Cite this