Oxidative Stress in Cancer

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  Defining the Oxidative Stress-Related Mechanisms by which Activation of the Transcription Factor Nrf2 Arrests and Resolves Liver Fibrosis

  Arthur, S. (Investigator), Dillon, J. (Investigator), Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator) & Henderson, C. (Investigator)

  Medical Research Council

  1/04/20 → 30/06/25

  Project: Research

  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Transcription Factor 58%
  • Oxidative Stress 56%
  • NFE2L2 55%
  • Transcription Factor Nrf2 50%

• Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

  Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator), Henderson, C. (Investigator), Keyse, S. (Investigator), Lamond, A. (Investigator) & Sutherland, C. (Investigator)

  Medical Research Council

  1/05/16 → 31/10/19

  Project: Research

  • NFE2L2 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 98%
  • Transcription Factor 67%
  • Kelch-like 65%
  • Associated Proteins 65%