Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms

Gwen Kennedy, Vance A. Spence, Margaret McLaren, Alexander Hill, Christine Underwood, Jill J. F. Belch

    Research output: Contribution to journalArticle

    214 Citations (Scopus)

    Abstract

    The aetiology of chronic fatigue syndrome (CFS) is unknown; however, recent evidence suggests excessive free radical (FR) generation may be involved. This study investigated for the first time levels of 8-iso-prostaglandin-F2a-isoprostanes alongside other plasma markers of oxidative stress in CFS patients and control subjects. Forty-seven patients (18 males, 29 females, mean age 48 [19–63] years) who fulfilled the Centres for Disease Control classification for CFS and 34 healthy volunteers (13 males, 21 females, 46 [19–63] years) were enrolled in the study. The CFS patients were divided into two groups; one group had previously defined cardiovascular (CV) risk factors of obesity and hypertension (group 1) and the second were normotensive and nonobese (group 2). Patients had significantly increased levels of isoprostanes (group 1, P = 0.007; group 2, P = 0.03, unpaired t test compared to controls) and oxidised low-density lipoproteins (group 2, P = 0.02) indicative of a FR attack on lipids. CFS patients also had significantly lower high-density lipoproteins (group 1, P = 0.011; group 2, P = 0.005). CFS symptoms correlated with isoprostane levels, but only in group 2 low CV risk CFS patients (isoprostanes correlated with; total symptom score P = 0.005; joint pain P = 0.002; postexertional malaise P = 0.027, Pearson). This is the first time that raised levels of the gold standard measure of in vivo oxidative stress (isoprostanes) and their association with CFS symptoms have been reported.
    Original languageEnglish
    Pages (from-to)584-589
    Number of pages6
    JournalFree Radical Biology and Medicine
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - Sep 2005

    Fingerprint

    Chronic Fatigue Syndrome
    Oxidative stress
    Isoprostanes
    Oxidative Stress
    Fatigue of materials
    Free Radicals
    Disease control
    Arthralgia
    HDL Lipoproteins
    Centers for Disease Control and Prevention (U.S.)
    LDL Lipoproteins
    Prostaglandins
    Healthy Volunteers
    Obesity
    Association reactions
    Hypertension
    Lipids
    Plasmas

    Keywords

    • Oxidative stress
    • Chronic fatigue syndrome
    • Free radicals
    • Cardiovascular risk factors

    Cite this

    Kennedy, Gwen ; Spence, Vance A. ; McLaren, Margaret ; Hill, Alexander ; Underwood, Christine ; Belch, Jill J. F. / Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. In: Free Radical Biology and Medicine. 2005 ; Vol. 39, No. 5. pp. 584-589.
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    Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. / Kennedy, Gwen; Spence, Vance A.; McLaren, Margaret; Hill, Alexander; Underwood, Christine; Belch, Jill J. F.

    In: Free Radical Biology and Medicine, Vol. 39, No. 5, 09.2005, p. 584-589.

    Research output: Contribution to journalArticle

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    AU - Spence, Vance A.

    AU - McLaren, Margaret

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    AU - Underwood, Christine

    AU - Belch, Jill J. F.

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