TY - JOUR
T1 - Oxidative stress management in the hair follicle
T2 - Could targeting NRF2 counter age-related hair disorders and beyond?
AU - Jadkauskaite, Laura
AU - Coulombe, Pierre A.
AU - Schäfer, Matthias
AU - Dinkova-Kostova, Albena T.
AU - Paus, Ralf
AU - Haslam, Iain S.
N1 - The writing of this article was support by a BBSRC CASE studentship in collaboration with Unilever, UK (L.J) and the NIHR Biomedical Research Centre (Inflammatory Hair Diseases programme) (R.P).
PY - 2017/7/27
Y1 - 2017/7/27
N2 - Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.
AB - Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.
KW - NRF2
KW - Oxidative stress
KW - Inflammation
KW - Hair greying
KW - Alopecia
KW - Chemotherapy and hair follicle
U2 - 10.1002/bies.201700029
DO - 10.1002/bies.201700029
M3 - Article
C2 - 28685843
SN - 0265-9247
VL - 39
SP - 1
EP - 9
JO - BioEssays
JF - BioEssays
IS - 8
M1 - 1700029
ER -