Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Laura Jadkauskaite, Pierre A. Coulombe, Matthias Schäfer, Albena T. Dinkova-Kostova, Ralf Paus, Iain S. Haslam (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.
    Original languageEnglish
    Article number1700029
    Pages (from-to)1-9
    Number of pages9
    JournalBioEssays
    Volume39
    Issue number8
    Early online date7 Jul 2017
    DOIs
    Publication statusPublished - 27 Jul 2017

    Keywords

    • NRF2
    • Oxidative stress
    • Inflammation
    • Hair greying
    • Alopecia
    • Chemotherapy and hair follicle

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