Oxygen free radicals and congestive heart failure

J J F Belch, A B Bridges, N Scott, M Chopra

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    388 Citations (Scopus)

    Abstract

    Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 µmol/l (IQR 379-480)) than in the controls (median 463 µmol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.
    Original languageEnglish
    Pages (from-to)245-248
    Number of pages4
    JournalBritish Heart Journal
    Volume65
    Issue number5
    DOIs
    Publication statusPublished - 1991

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