Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations

Y. C. O'Callaghan; J. A. Woods; N. M. O'Brien

doi:10.1007/s003940050075

Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations

Y. C. O'Callaghan, J. A. Woods, N. M. O'Brien

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Cholesterol oxidation products (oxysterols) are commonly found in foods of animal origin and are also produced endogenously in the body. Oxysterols are cytotoxic to certain cell lines and in some cases have been shown to induce apoptosis. The aim of this study was to investigate the effects of 7beta-hydroxy-cholesterol (7beta-OHC) and 25-hydroxycholesterol (25-OHC) on cytotoxicity and induction of apoptosis in U937 and HepG2 cells, treated in media containing either 2.5% foetal calf serum (FCS) or 10% FCS to examine the effect of increasing the cholesterol level.

Original language	English
Pages (from-to)	255-262
Number of pages	8
Journal	European Journal of Nutrition
Volume	38
Issue number	6
DOIs	https://doi.org/10.1007/s003940050075
Publication status	Published - 1999

Access to Document

10.1007/s003940050075

Cite this

@article{b454068af15e42629236c292ec374b75,

title = "Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations",

abstract = "Cholesterol oxidation products (oxysterols) are commonly found in foods of animal origin and are also produced endogenously in the body. Oxysterols are cytotoxic to certain cell lines and in some cases have been shown to induce apoptosis. The aim of this study was to investigate the effects of 7beta-hydroxy-cholesterol (7beta-OHC) and 25-hydroxycholesterol (25-OHC) on cytotoxicity and induction of apoptosis in U937 and HepG2 cells, treated in media containing either 2.5% foetal calf serum (FCS) or 10% FCS to examine the effect of increasing the cholesterol level.",

author = "O'Callaghan, {Y. C.} and Woods, {J. A.} and O'Brien, {N. M.}",

year = "1999",

doi = "10.1007/s003940050075",

language = "English",

volume = "38",

pages = "255--262",

journal = "European Journal of Nutrition",

issn = "1436-6207",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "6",

}

TY - JOUR

T1 - Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations

AU - O'Callaghan, Y. C.

AU - Woods, J. A.

AU - O'Brien, N. M.

PY - 1999

Y1 - 1999

N2 - Cholesterol oxidation products (oxysterols) are commonly found in foods of animal origin and are also produced endogenously in the body. Oxysterols are cytotoxic to certain cell lines and in some cases have been shown to induce apoptosis. The aim of this study was to investigate the effects of 7beta-hydroxy-cholesterol (7beta-OHC) and 25-hydroxycholesterol (25-OHC) on cytotoxicity and induction of apoptosis in U937 and HepG2 cells, treated in media containing either 2.5% foetal calf serum (FCS) or 10% FCS to examine the effect of increasing the cholesterol level.

AB - Cholesterol oxidation products (oxysterols) are commonly found in foods of animal origin and are also produced endogenously in the body. Oxysterols are cytotoxic to certain cell lines and in some cases have been shown to induce apoptosis. The aim of this study was to investigate the effects of 7beta-hydroxy-cholesterol (7beta-OHC) and 25-hydroxycholesterol (25-OHC) on cytotoxicity and induction of apoptosis in U937 and HepG2 cells, treated in media containing either 2.5% foetal calf serum (FCS) or 10% FCS to examine the effect of increasing the cholesterol level.

U2 - 10.1007/s003940050075

DO - 10.1007/s003940050075

M3 - Article

C2 - 10784381

SN - 1436-6207

VL - 38

SP - 255

EP - 262

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 6

ER -

Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations

Abstract

Access to Document

Fingerprint

Cite this