P3OO and smooth eye pursuit: concordance of abnormalities and relation to clinical features in DSM-III schizophrenia

E.K.P. Ebmeier, D.D. Potter, R.H.B. Cochrane, A.R. Mackenzie, H. McAllister, J.A.O. Besson, E.A. Salzen

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    Twenty-five DSM-III-diagnosed schizophrenics and 37 normal and age-matched controls were examined using an oddball paradigm for the generation of P300 and smooth eye-pursuit tasks. Results were compared between groups and related to clinical characteristics, including a family history of psychiatric illness. Group differences were found for P300 amplitudes, latencies and eye-tracking. A family history of psychiatric illness was associated with normal eye-tracking in patients. Small P300 amplitudes alone and in combination with long P300 latencies were associated with a family history in controls.
    Original languageEnglish
    Pages (from-to)283-288
    Number of pages6
    JournalActa Psychiatrica Scandinavica
    Issue number4
    Publication statusPublished - 1990


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