Since its discovery in 1979, many different roles for the tumor suppressor protein p53 in tumorigenesis have been described. Correct p53 function is required for proper regulation of cell division, apoptosis, senescence, and the responses to cellular stresses such as DNA damage and hypoxia. Indeed, mutations in p53 are observed in as many as 50% of human cancers.1 However, recent reports have highlighted an emerging role for p53 in anti-viral immunity. This chapter reviews the available literature on p53 and the body’s immune response, and how p53 may link immunity and cancer.
|Title of host publication||p53|
|Editors||Ayeda Ayed, Theodore Hupp|
|Place of Publication||Austin, TX|
|Number of pages||9|
|Publication status||Published - 2010|
|Name||Molecular Biology Intelligence Unit|