p53 and immunity

Vikram Narayan, Sarah E. M. Meek (Contributing member), Kathryn Ball (Lead / Corresponding author)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    Abstract

    Since its discovery in 1979, many different roles for the tumor suppressor protein p53 in tumorigenesis have been described. Correct p53 function is required for proper regulation of cell division, apoptosis, senescence, and the responses to cellular stresses such as DNA damage and hypoxia. Indeed, mutations in p53 are observed in as many as 50% of human cancers.1 However, recent reports have highlighted an emerging role for p53 in anti-viral immunity. This chapter reviews the available literature on p53 and the body’s immune response, and how p53 may link immunity and cancer.
    Original languageEnglish
    Title of host publicationp53
    EditorsAyeda Ayed, Theodore Hupp
    Place of PublicationAustin, TX
    PublisherLandes Bioscience
    Pages178-186
    Number of pages9
    ISBN (Electronic)9781441982315
    ISBN (Print)9781441982308
    DOIs
    Publication statusPublished - 2010

    Publication series

    NameMolecular Biology Intelligence Unit
    Volume1
    ISSN (Print)1431-0414

    Keywords

    • p53
    • IMMUNITY

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