p53 and immunity

Vikram Narayan; Sarah E. M. Meek; Kathryn Ball

doi:10.1007/978-1-4419-8231-5_12

p53 and immunity

Vikram Narayan, Sarah E. M. Meek (Contributing member), Kathryn Ball (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Abstract

Since its discovery in 1979, many different roles for the tumor suppressor protein p53 in tumorigenesis have been described. Correct p53 function is required for proper regulation of cell division, apoptosis, senescence, and the responses to cellular stresses such as DNA damage and hypoxia. Indeed, mutations in p53 are observed in as many as 50% of human cancers.1 However, recent reports have highlighted an emerging role for p53 in anti-viral immunity. This chapter reviews the available literature on p53 and the body’s immune response, and how p53 may link immunity and cancer.

Original language	English
Title of host publication	p53
Editors	Ayeda Ayed, Theodore Hupp
Place of Publication	Austin, TX
Publisher	Landes Bioscience
Pages	178-186
Number of pages	9
ISBN (Electronic)	9781441982315
ISBN (Print)	9781441982308
DOIs	https://doi.org/10.1007/978-1-4419-8231-5_12
Publication status	Published - 2010

Publication series

Name	Molecular Biology Intelligence Unit
Volume	1
ISSN (Print)	1431-0414

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

p53
IMMUNITY

Access to Document

10.1007/978-1-4419-8231-5_12

Cite this

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abstract = "Since its discovery in 1979, many different roles for the tumor suppressor protein p53 in tumorigenesis have been described. Correct p53 function is required for proper regulation of cell division, apoptosis, senescence, and the responses to cellular stresses such as DNA damage and hypoxia. Indeed, mutations in p53 are observed in as many as 50\% of human cancers.1 However, recent reports have highlighted an emerging role for p53 in anti-viral immunity. This chapter reviews the available literature on p53 and the body{\textquoteright}s immune response, and how p53 may link immunity and cancer.",

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A2 - Hupp, Theodore

PY - 2010

Y1 - 2010

N2 - Since its discovery in 1979, many different roles for the tumor suppressor protein p53 in tumorigenesis have been described. Correct p53 function is required for proper regulation of cell division, apoptosis, senescence, and the responses to cellular stresses such as DNA damage and hypoxia. Indeed, mutations in p53 are observed in as many as 50% of human cancers.1 However, recent reports have highlighted an emerging role for p53 in anti-viral immunity. This chapter reviews the available literature on p53 and the body’s immune response, and how p53 may link immunity and cancer.

AB - Since its discovery in 1979, many different roles for the tumor suppressor protein p53 in tumorigenesis have been described. Correct p53 function is required for proper regulation of cell division, apoptosis, senescence, and the responses to cellular stresses such as DNA damage and hypoxia. Indeed, mutations in p53 are observed in as many as 50% of human cancers.1 However, recent reports have highlighted an emerging role for p53 in anti-viral immunity. This chapter reviews the available literature on p53 and the body’s immune response, and how p53 may link immunity and cancer.

KW - p53

KW - IMMUNITY

U2 - 10.1007/978-1-4419-8231-5_12

DO - 10.1007/978-1-4419-8231-5_12

M3 - Chapter (peer-reviewed)

SN - 9781441982308

T3 - Molecular Biology Intelligence Unit

SP - 178

EP - 186

BT - p53

PB - Landes Bioscience

CY - Austin, TX

ER -

p53 and immunity

Abstract

Publication series

UN SDGs

Keywords

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