p53 and Mdm2: not all cells are equal

P. J. Coates

doi:10.1002/path.2275

p53 and Mdm2: not all cells are equal

P. J. Coates

Research output: Contribution to journal › Editorial › peer-review

7 Citations (Scopus)

Abstract

The human TP53 gene is well known as a tumour suppressor. Less well appreciated are the potential roles of p53 in regulating postnatal development and the cell-type specific effects of p53. In this issue of the Journal of Pathology, Lozano and colleagues show that p53 has the ability to block progenitor cell expansion in haematopoiesis and spermatogenesis but not in specific epithelial tissues. These data challenge the view that p53 acts equally in all cell types and have important implications for the applicability of p53 therapeutics in the treatment of human cancers.

Original language	English
Pages (from-to)	357-9
Number of pages	3
Journal	Journal of Pathology
Volume	213
Issue number	4
DOIs	https://doi.org/10.1002/path.2275
Publication status	Published - Dec 2007

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SDG 3 Good Health and Well-being

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10.1002/path.2275

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title = "p53 and Mdm2: not all cells are equal",

abstract = "The human TP53 gene is well known as a tumour suppressor. Less well appreciated are the potential roles of p53 in regulating postnatal development and the cell-type specific effects of p53. In this issue of the Journal of Pathology, Lozano and colleagues show that p53 has the ability to block progenitor cell expansion in haematopoiesis and spermatogenesis but not in specific epithelial tissues. These data challenge the view that p53 acts equally in all cell types and have important implications for the applicability of p53 therapeutics in the treatment of human cancers.",

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AB - The human TP53 gene is well known as a tumour suppressor. Less well appreciated are the potential roles of p53 in regulating postnatal development and the cell-type specific effects of p53. In this issue of the Journal of Pathology, Lozano and colleagues show that p53 has the ability to block progenitor cell expansion in haematopoiesis and spermatogenesis but not in specific epithelial tissues. These data challenge the view that p53 acts equally in all cell types and have important implications for the applicability of p53 therapeutics in the treatment of human cancers.

U2 - 10.1002/path.2275

DO - 10.1002/path.2275

M3 - Editorial

C2 - 17973240

SN - 0022-3417

VL - 213

SP - 357

EP - 359

JO - Journal of Pathology

JF - Journal of Pathology

IS - 4

ER -

p53 and Mdm2: not all cells are equal

Abstract

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