P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells

Janis M. Burns; Paul A. Campbell

doi:10.1063/1.3607936

P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells

Janis M. Burns, Paul A. Campbell

Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Mutated p53 can be found in approximately half of all human cancers. Strategies which seek to restore, or at least exercise a level of external control over, p53 functionality are thus potentially useful as adjuncts to therapy. Here, we report our preliminary measurements in this area, and demonstrate that short-burst pulsed ultrasound can indeed affect p53 activity. Specifically, we have observed that expression of the p53 protein can be regulated in the period immediately following low intensity short pulse (millisecond) ultrasound exposure, and that altered activity levels return to basal levels over a 24 hour period post-insonation.

Original language	English
Title of host publication	10th International Symposium on Therapeutic Ultrasound (ISTU 2010)
Editors	Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar
Place of Publication	Melville
Publisher	American Institute of Physics
Pages	371-376
Number of pages	6
ISBN (Print)	9780735409170
DOIs	https://doi.org/10.1063/1.3607936
Publication status	Published - 2011
Event	10th International Symposium on Therapeutic Ultrasound - Tokyo, Japan Duration: 9 Jun 2010 → 12 Jun 2010 http://www.fel.t.u-tokyo.ac.jp/istu/

Publication series

Name	AIP conference proceedings
Publisher	American Institute of Physics
Volume	1359

Conference

Conference	10th International Symposium on Therapeutic Ultrasound
Abbreviated title	ISTU 2010
Country/Territory	Japan
City	Tokyo
Period	9/06/10 → 12/06/10
Internet address	http://www.fel.t.u-tokyo.ac.jp/istu/

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http://copac.jisc.ac.uk/search?&isn=9780735409170

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Burns, J. M., & Campbell, P. A. (2011). P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells. In Y. Matsumoto, L. A. Crum, & G. R. T. Haar (Eds.), 10th International Symposium on Therapeutic Ultrasound (ISTU 2010) (pp. 371-376). (AIP conference proceedings ; Vol. 1359). American Institute of Physics. https://doi.org/10.1063/1.3607936

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title = "P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells",

abstract = "Mutated p53 can be found in approximately half of all human cancers. Strategies which seek to restore, or at least exercise a level of external control over, p53 functionality are thus potentially useful as adjuncts to therapy. Here, we report our preliminary measurements in this area, and demonstrate that short-burst pulsed ultrasound can indeed affect p53 activity. Specifically, we have observed that expression of the p53 protein can be regulated in the period immediately following low intensity short pulse (millisecond) ultrasound exposure, and that altered activity levels return to basal levels over a 24 hour period post-insonation.",

author = "Burns, {Janis M.} and Campbell, {Paul A.}",

year = "2011",

doi = "10.1063/1.3607936",

language = "English",

isbn = "9780735409170",

series = "AIP conference proceedings ",

publisher = "American Institute of Physics",

pages = "371--376",

editor = "Matsumoto, {Yoichiro } and Crum, {Lawrence A. } and Haar, {Gail Reinette ter }",

booktitle = "10th International Symposium on Therapeutic Ultrasound (ISTU 2010)",

address = "United States",

note = "10th International Symposium on Therapeutic Ultrasound, ISTU 2010 ; Conference date: 09-06-2010 Through 12-06-2010",

url = "http://www.fel.t.u-tokyo.ac.jp/istu/",

}

Burns, JM & Campbell, PA 2011, P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells. in Y Matsumoto, LA Crum & GRT Haar (eds), 10th International Symposium on Therapeutic Ultrasound (ISTU 2010) . AIP conference proceedings , vol. 1359, American Institute of Physics, Melville, pp. 371-376, 10th International Symposium on Therapeutic Ultrasound, Tokyo, Japan, 9/06/10. https://doi.org/10.1063/1.3607936

P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells. / Burns, Janis M.; Campbell, Paul A.
10th International Symposium on Therapeutic Ultrasound (ISTU 2010) . ed. / Yoichiro Matsumoto; Lawrence A. Crum; Gail Reinette ter Haar. Melville: American Institute of Physics, 2011. p. 371-376 (AIP conference proceedings ; Vol. 1359).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - P53 response to ultrasound

T2 - 10th International Symposium on Therapeutic Ultrasound

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AU - Campbell, Paul A.

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N2 - Mutated p53 can be found in approximately half of all human cancers. Strategies which seek to restore, or at least exercise a level of external control over, p53 functionality are thus potentially useful as adjuncts to therapy. Here, we report our preliminary measurements in this area, and demonstrate that short-burst pulsed ultrasound can indeed affect p53 activity. Specifically, we have observed that expression of the p53 protein can be regulated in the period immediately following low intensity short pulse (millisecond) ultrasound exposure, and that altered activity levels return to basal levels over a 24 hour period post-insonation.

AB - Mutated p53 can be found in approximately half of all human cancers. Strategies which seek to restore, or at least exercise a level of external control over, p53 functionality are thus potentially useful as adjuncts to therapy. Here, we report our preliminary measurements in this area, and demonstrate that short-burst pulsed ultrasound can indeed affect p53 activity. Specifically, we have observed that expression of the p53 protein can be regulated in the period immediately following low intensity short pulse (millisecond) ultrasound exposure, and that altered activity levels return to basal levels over a 24 hour period post-insonation.

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T3 - AIP conference proceedings

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BT - 10th International Symposium on Therapeutic Ultrasound (ISTU 2010)

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PB - American Institute of Physics

CY - Melville

Y2 - 9 June 2010 through 12 June 2010

ER -

P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells

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