p53 transcriptional pathways in breast cancer: the good, the bad and the complex

Alastair M. Thompson, David P. Lane

    Research output: Contribution to journalEditorialpeer-review

    10 Citations (Scopus)

    Abstract

    A p53 network immunohistochemically-based signature to discriminate between good and poor prognosis breast cancer would have clinical relevance, given the key role of p53 in malignancy and response to therapy. Utilizing a five-protein signature of p53/mdm2/mdm4/bcl2/p21 discriminates good-prognosis and poor-prognosis patient groups, based on the functionality of the p53 network. However, the relationship of this five-protein signature to p53 mutation, the wide range of breast cancer therapies now in use and the over-70 age group remain uncertain. Nonetheless, confirmation of the signature in two independent series suggests that this approach should be considered in further case series and in the context of clinical trials. Copyright (C) 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

    Original languageEnglish
    Pages (from-to)401-403
    Number of pages3
    JournalJournal of Pathology
    Volume220
    Issue number4
    DOIs
    Publication statusPublished - Mar 2010

    Keywords

    • breast cancer
    • prognosis
    • p53
    • mdm2
    • bcl2
    • p21
    • immunohistochemistry
    • signature
    • TP53 GENE-MUTATIONS
    • NEOADJUVANT TREATMENT
    • EXPRESSION
    • IMMUNOHISTOCHEMISTRY
    • CHEMOTHERAPY
    • RADIOTHERAPY
    • SURVIVAL
    • ISOFORMS
    • TUMORS

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