p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress

F. Murray-Zmijewski, D. Lane, J-C. Bourdon

    Research output: Contribution to journalReview article

    369 Citations (Scopus)

    Abstract

    p63, p73 and p53 compose a family of transcription factors involved in cell response to stress and development. p53 is the most frequently mutated gene in cancer (50%) and loss of p53 activity is considered to be ubiquitous to all cancers. Recent publications may have a profound impact on our understanding of p53 tumour suppressor activity. p63, p73 and p53 genes have a dual gene structure conserved in drosophila, zebrafish and man. They encode for multiple p63, p73 or p53 proteins containing different protein domains (isoforms) due to multiple splicing, alternative promoter and alternative initiation of translation. In this review, we describe the different isoforms of p63, p73, p53 and their roles in development and cancer. The changes in the interactions between p53, p63 and p73 isoforms are likely to be fundamental to our understanding in the transition between normal cell cycling and the onset of tumour formation.

    Original languageEnglish
    Pages (from-to)962-972
    Number of pages11
    JournalCell Death & Differentiation
    Volume13
    Issue number6
    DOIs
    Publication statusPublished - Jun 2006

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