p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

Xiaolian Gu, Philip J Coates, Linda Boldrup, Karin Nylander

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.
    Original languageEnglish
    Pages (from-to)26-34
    Number of pages9
    JournalCancer Letters
    Volume263
    Issue number1
    DOIs
    Publication statusPublished - 2008

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