p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

Xiaolian Gu; Philip J Coates; Linda Boldrup; Karin Nylander

doi:10.1016/j.canlet.2007.12.011

p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

Xiaolian Gu, Philip J Coates, Linda Boldrup, Karin Nylander

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Abstract

The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.

Original language	English
Pages (from-to)	26-34
Number of pages	9
Journal	Cancer Letters
Volume	263
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2007.12.011
Publication status	Published - 2008

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title = "p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck",

abstract = "The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.",

author = "Xiaolian Gu and Coates, {Philip J} and Linda Boldrup and Karin Nylander",

year = "2008",

doi = "10.1016/j.canlet.2007.12.011",

language = "English",

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journal = "Cancer Letters",

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T1 - p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

AU - Gu, Xiaolian

AU - Coates, Philip J

AU - Boldrup, Linda

AU - Nylander, Karin

PY - 2008

Y1 - 2008

N2 - The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.

AB - The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.

U2 - 10.1016/j.canlet.2007.12.011

DO - 10.1016/j.canlet.2007.12.011

M3 - Article

C2 - 18194839

SN - 0304-3835

VL - 263

SP - 26

EP - 34

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

Abstract

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