Pacing-induced heart disease: understanding the pathophysiology and improving outcomes

Douglas H. J. Elder, Chim C. Lang, Anna Maria Choy

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)


    Pacemaker implantation remains the only therapeutic option that improves morbidity and mortality for patients with symptomatic bradycardia. However, pacing from the right ventricular apex can induce dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function and may be associated with adverse cardiovascular outcomes. This article reviews the current knowledge on the pathophysiology of pacing-induced cardiovascular disease and current strategies to avoid and mitigate the adverse effects of right ventricular pacing.
    Original languageEnglish
    Pages (from-to)877-886
    Number of pages10
    JournalExpert Review of Cardiovascular Therapy
    Issue number7
    Publication statusPublished - 1 Jul 2011


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