Pain in patients with transverse myelitis and its relationship to aquaporin 4 antibody status

Yazhuo Kong, Helen Okoruwa, Jon Revis, George Tackley, Maria Isabel Leite, Michael Lee, Irene Tracey, Jacqueline Palace (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)


    Pain in transverse myelitis has been poorly studied. The aim of the study was to investigate the relationship between transverse myelitis related pain and disability, quality of life, anxiety and depression, cognitive-affective states in neuromyelitis optica (NMO) patients and aquaporin4 antibody status (AQP4-Ab +ve as positive and AQP4-Ab − ve as negative). Transverse myelitis patients (44 in total; 29 AQP4-Ab +ve and 15 AQP4-Ab − ve) completed questionnaires including Pain Severity Index (PSI), Pain Catastrophising Scale (PCS), Hospital Anxiety and Depression Scale (HADS), Short Form-36 quality of life (SF-36 QOL). Clinical details such as disability, gender, age and spinal cord lesion type (short or long lesion) were noted. Correlation and multiple linear regression tests were performed using these clinical scores. Pain was found to be correlated strongly with quality of life in both groups but only correlated with disability in the AQP4-Ab + ve group. PCS, HADS and EDMUS were found to be highly correlated with pain severity using partial correlation, however, a stronger relationship between pain severity and PCS was found in the AQP4-Ab − ve group. Multiple regression analysis showed that pain severity was the most important factor for quality of life but not disability or anxiety and depression symptoms in the whole patient group. We confirm that pain is an important symptom of transverse myelitis and has more influence on quality of life than disability despite health services being predominantly focused on the latter. There may be different factors associated with pain between AQP4-Ab + ve and − ve patients.

    Original languageEnglish
    Pages (from-to)84-88
    Number of pages5
    JournalJournal of the Neurological Sciences
    Publication statusPublished - 22 Jun 2016


    • Aquaporin-4 antibodies
    • Neuromyelitis optica
    • Neuropathic pain
    • Quality of life
    • Transverse myelitis

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology


    Dive into the research topics of 'Pain in patients with transverse myelitis and its relationship to aquaporin 4 antibody status'. Together they form a unique fingerprint.

    Cite this