Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

John James Aird; Aisling U. Nic An Riogh; Stewart Fleming; R. Gordon Hislop; Paul Sweeney; Nick Mayer

doi:10.1177/1066896917716772

Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

John James Aird (Lead / Corresponding author), Aisling U. Nic An Riogh, Stewart Fleming, R. Gordon Hislop, Paul Sweeney, Nick Mayer

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

Original language	English
Pages (from-to)	745-750
Number of pages	6
Journal	International Journal of Surgical Pathology
Volume	28
Issue number	8
Early online date	2 Jul 2017
DOIs	https://doi.org/10.1177/1066896917716772
Publication status	Published - 1 Dec 2017

Keywords

Journal article
Renal cell carcinoma
Papillary
Heterologous
Sarcomatoid
osteosarcoma
Osteosarcomatous
Cytogenetics
Molecular

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title = "Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature",

abstract = "Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.",

keywords = "Journal article, Renal cell carcinoma , Papillary , Heterologous , Sarcomatoid , osteosarcoma, Osteosarcomatous , Cytogenetics , Molecular",

author = "Aird, {John James} and {Nic An Riogh}, {Aisling U.} and Stewart Fleming and Hislop, {R. Gordon} and Paul Sweeney and Nick Mayer",

note = "The author(s) received no financial support for the research, authorship, and/or publication of this article.",

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Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature. / Aird, John James (Lead / Corresponding author); Nic An Riogh, Aisling U.; Fleming, Stewart et al.
In: International Journal of Surgical Pathology, Vol. 28, No. 8, 01.12.2017, p. 745-750.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation

T2 - A Case Report With Molecular Genetic Analysis and Review of the Literature

AU - Aird, John James

AU - Nic An Riogh, Aisling U.

AU - Fleming, Stewart

AU - Hislop, R. Gordon

AU - Sweeney, Paul

AU - Mayer, Nick

N1 - The author(s) received no financial support for the research, authorship, and/or publication of this article.

PY - 2017/12/1

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N2 - Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

AB - Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

KW - Journal article

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KW - Papillary

KW - Heterologous

KW - Sarcomatoid

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Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

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