Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation

A Case Report With Molecular Genetic Analysis and Review of the Literature

John James Aird (Lead / Corresponding author), Aisling U. Nic An Riogh, Stewart Fleming, R. Gordon Hislop, Paul Sweeney, Nick Mayer

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

    Original languageEnglish
    Pages (from-to)745-750
    Number of pages6
    JournalInternational Journal of Surgical Pathology
    Volume28
    Issue number8
    Early online date2 Jul 2017
    DOIs
    Publication statusPublished - 1 Dec 2017

    Fingerprint

    Renal Cell Carcinoma
    Molecular Biology
    Chromosomes, Human, Pair 7
    Osteosarcoma
    Osteogenesis
    Cytogenetics
    Tomography
    Kidney

    Keywords

    • Journal article
    • Renal cell carcinoma
    • Papillary
    • Heterologous
    • Sarcomatoid
    • osteosarcoma
    • Osteosarcomatous
    • Cytogenetics
    • Molecular

    Cite this

    @article{f07ce18f0d4749659974b0f6400ae4a2,
    title = "Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature",
    abstract = "Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.",
    keywords = "Journal article, Renal cell carcinoma , Papillary , Heterologous , Sarcomatoid , osteosarcoma, Osteosarcomatous , Cytogenetics , Molecular",
    author = "Aird, {John James} and {Nic An Riogh}, {Aisling U.} and Stewart Fleming and Hislop, {R. Gordon} and Paul Sweeney and Nick Mayer",
    note = "The author(s) received no financial support for the research, authorship, and/or publication of this article.",
    year = "2017",
    month = "12",
    day = "1",
    doi = "10.1177/1066896917716772",
    language = "English",
    volume = "28",
    pages = "745--750",
    journal = "International Journal of Surgical Pathology",
    issn = "1066-8969",
    publisher = "SAGE Publications",
    number = "8",

    }

    Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation : A Case Report With Molecular Genetic Analysis and Review of the Literature. / Aird, John James (Lead / Corresponding author); Nic An Riogh, Aisling U.; Fleming, Stewart; Hislop, R. Gordon; Sweeney, Paul; Mayer, Nick.

    In: International Journal of Surgical Pathology, Vol. 28, No. 8, 01.12.2017, p. 745-750.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation

    T2 - A Case Report With Molecular Genetic Analysis and Review of the Literature

    AU - Aird, John James

    AU - Nic An Riogh, Aisling U.

    AU - Fleming, Stewart

    AU - Hislop, R. Gordon

    AU - Sweeney, Paul

    AU - Mayer, Nick

    N1 - The author(s) received no financial support for the research, authorship, and/or publication of this article.

    PY - 2017/12/1

    Y1 - 2017/12/1

    N2 - Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

    AB - Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

    KW - Journal article

    KW - Renal cell carcinoma

    KW - Papillary

    KW - Heterologous

    KW - Sarcomatoid

    KW - osteosarcoma

    KW - Osteosarcomatous

    KW - Cytogenetics

    KW - Molecular

    UR - http://journals.sagepub.com/doi/full/10.1177/1066896917716772

    U2 - 10.1177/1066896917716772

    DO - 10.1177/1066896917716772

    M3 - Article

    VL - 28

    SP - 745

    EP - 750

    JO - International Journal of Surgical Pathology

    JF - International Journal of Surgical Pathology

    SN - 1066-8969

    IS - 8

    ER -