Abstract
Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.
| Original language | English |
|---|---|
| Pages (from-to) | 84-98 |
| Number of pages | 15 |
| Journal | Journal of Internal Medicine |
| Volume | 266 |
| Issue number | 1 |
| Early online date | 10 Jun 2009 |
| DOIs | |
| Publication status | Published - Jul 2009 |
Keywords
- Amino Acid Sequence
- Animals
- Genetic Predisposition to Disease
- Humans
- Hyperparathyroidism/genetics
- Jaw Neoplasms/genetics
- Molecular Sequence Data
- Neoplasm Proteins/genetics
- Neoplastic Syndromes, Hereditary/genetics
- Parathyroid Neoplasms/genetics
- Tumor Suppressor Proteins/genetics