Parafibromin-functional insights

P. J. Newey, M. R. Bowl, R. V. Thakker

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.

Original languageEnglish
Pages (from-to)84-98
Number of pages15
JournalJournal of Internal Medicine
Volume266
Issue number1
Early online date10 Jun 2009
DOIs
Publication statusPublished - Jul 2009

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Keywords

  • Amino Acid Sequence
  • Animals
  • Genetic Predisposition to Disease
  • Humans
  • Hyperparathyroidism/genetics
  • Jaw Neoplasms/genetics
  • Molecular Sequence Data
  • Neoplasm Proteins/genetics
  • Neoplastic Syndromes, Hereditary/genetics
  • Parathyroid Neoplasms/genetics
  • Tumor Suppressor Proteins/genetics

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