Parasite glycoconjugates. Part 1: the synthesis of some early and related intermediates in the biosynthetic pathway of glycosyl-phosphatidylinositol membrane anchors

Sylvain Cottaz, John S. Brimacombe, Michael A. J. Ferguson

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The enantio-pure 1D- and 1L-myo-inositol derivatives 3D and 3L have been used to prepare sodium 1D-6-O-(2-amino-2-deoxy-a-D-glucopyranosyl)-myo- inositol sn-2,3-dipalmitoyloxypropyl phosphate 21 and a related 1,6-disubstituted 1L-myo-inositol 28, respectively. The hydrogenphosphonate approach was effective in coupling together the phosphonolipid moiety 16 and the protected 6-O-(2-azido-2-deoxy-a-D-glucopyranosyl)-myo-inositols 15 and 24, respectively.
    Original languageEnglish
    Pages (from-to)2945-2951
    Number of pages7
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number23
    DOIs
    Publication statusPublished - 1 Jan 1993

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