Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Andrew J.  Ross; Irina A.  Ivanova; Michael A. J.  Ferguson; Andrei V.  Nikolaev

doi:10.1039/B004653L

Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Andrew J. Ross, Irina A. Ivanova, Michael A. J. Ferguson, Andrei V. Nikolaev

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A set of phosphodisaccharides, substrate analogues, which will be used to study acceptor-substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs-Knorr and trichloroacetimidate methods for the glycosylation reactions, S(N)2 nucleophilic displacement of a triflic ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.

Original language	English
Pages (from-to)	72-81
Number of pages	10
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	1
DOIs	https://doi.org/10.1039/B004653L
Publication status	Published - 7 Jan 2001

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title = "Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania",

abstract = "A set of phosphodisaccharides, substrate analogues, which will be used to study acceptor-substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs-Knorr and trichloroacetimidate methods for the glycosylation reactions, S(N)2 nucleophilic displacement of a triflic ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.",

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Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. / Ross, Andrew J. ; Ivanova, Irina A. ; Ferguson, Michael A. J. et al.
In: Journal of the Chemical Society - Perkin Transactions 1, No. 1, 07.01.2001, p. 72-81.

Research output: Contribution to journal › Article › peer-review

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AB - A set of phosphodisaccharides, substrate analogues, which will be used to study acceptor-substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs-Knorr and trichloroacetimidate methods for the glycosylation reactions, S(N)2 nucleophilic displacement of a triflic ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.

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Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

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