Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Andrew J. Ross, Irina A. Ivanova, Michael A. J. Ferguson, Andrei V. Nikolaev

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    Abstract

    A set of phosphodisaccharides, substrate analogues, which will be used to study acceptor-substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs-Knorr and trichloroacetimidate methods for the glycosylation reactions, S(N)2 nucleophilic displacement of a triflic ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.

    Original languageEnglish
    Pages (from-to)72-81
    Number of pages10
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number1
    DOIs
    Publication statusPublished - 7 Jan 2001

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