Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Dmitry V. Yashunsky, Yury E. Tsvetkov, Michael A. J. Ferguson, Andrei V. Nikolaev

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A set of phosphodisaccharides, structural analogues of the beta-D-galactosyl-(1-->4)-alpha-D-mannosyl phosphate 1, are synthesized using the Koenigs-Knorr method for the glycosylation reactions and the glycosyl hydrogenphosphonate method for phosphorylation. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania alpha-D-mannosylphosphate transferase.

    Original languageEnglish
    Pages (from-to)242-256
    Number of pages15
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number2
    DOIs
    Publication statusPublished - 2002

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