Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Dmitry V.  Yashunsky; Yury E.  Tsvetkov; Michael A. J.  Ferguson; Andrei V.  Nikolaev

doi:10.1039/b106182h

Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Dmitry V. Yashunsky
, Yury E. Tsvetkov
, Michael A. J. Ferguson
, Andrei V. Nikolaev

Research output: Contribution to journal › Article › peer-review

Abstract

A set of phosphodisaccharides, structural analogues of the beta-D-galactosyl-(1-->4)-alpha-D-mannosyl phosphate 1, are synthesized using the Koenigs-Knorr method for the glycosylation reactions and the glycosyl hydrogenphosphonate method for phosphorylation. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania alpha-D-mannosylphosphate transferase.

Original language	English
Pages (from-to)	242-256
Number of pages	15
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	2
DOIs	https://doi.org/10.1039/b106182h
Publication status	Published - 2002

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Yashunsky, D. V., Tsvetkov, Y. E., Ferguson, M. A. J., & Nikolaev, A. V. (2002). Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. Journal of the Chemical Society - Perkin Transactions 1, (2), 242-256. https://doi.org/10.1039/b106182h

Yashunsky, Dmitry V. ; Tsvetkov, Yury E. ; Ferguson, Michael A. J. et al. / Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. In: Journal of the Chemical Society - Perkin Transactions 1. 2002 ; No. 2. pp. 242-256.

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abstract = "A set of phosphodisaccharides, structural analogues of the beta-D-galactosyl-(1-->4)-alpha-D-mannosyl phosphate 1, are synthesized using the Koenigs-Knorr method for the glycosylation reactions and the glycosyl hydrogenphosphonate method for phosphorylation. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania alpha-D-mannosylphosphate transferase.",

author = "Yashunsky, \{Dmitry V.\} and Tsvetkov, \{Yury E.\} and Ferguson, \{Michael A. J.\} and Nikolaev, \{Andrei V.\}",

year = "2002",

doi = "10.1039/b106182h",

language = "English",

pages = "242--256",

journal = "Journal of the Chemical Society - Perkin Transactions 1",

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Yashunsky, DV, Tsvetkov, YE, Ferguson, MAJ & Nikolaev, AV 2002, 'Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania', Journal of the Chemical Society - Perkin Transactions 1, no. 2, pp. 242-256. https://doi.org/10.1039/b106182h

Parasite glycoconjugates. Part 12. Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. / Yashunsky, Dmitry V. ; Tsvetkov, Yury E. ; Ferguson, Michael A. J. et al.
In: Journal of the Chemical Society - Perkin Transactions 1, No. 2, 2002, p. 242-256.

Research output: Contribution to journal › Article › peer-review

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