Parasite glycoconjugates. Part 3: synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Sylvain Cottaz, John S. Brimacombe, Michael A. J. Ferguson

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn-2,3- bis(palmitoyloxy)propyl phosphate] 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei. Such analogues as 2-deoxy-a-D-Glcp-PI 25 and a-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.
    Original languageEnglish
    Pages (from-to)1673-1678
    Number of pages6
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number13
    Publication statusPublished - 1 Jan 1995

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