TY - JOUR
T1 - Parasite glycoconjugates. Part 3
T2 - synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors
AU - Cottaz, Sylvain
AU - Brimacombe, John S.
AU - Ferguson, Michael A. J.
N1 - Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn-2,3- bis(palmitoyloxy)propyl phosphate] 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei. Such analogues as 2-deoxy-a-D-Glcp-PI 25 and a-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.
AB - Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn-2,3- bis(palmitoyloxy)propyl phosphate] 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei. Such analogues as 2-deoxy-a-D-Glcp-PI 25 and a-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.
UR - http://www.scopus.com/inward/record.url?scp=37049071882&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:37049071882
SN - 1472-7781
SP - 1673
EP - 1678
JO - Journal of the Chemical Society - Perkin Transactions 1
JF - Journal of the Chemical Society - Perkin Transactions 1
IS - 13
ER -