Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn-2,3- bis(palmitoyloxy)propyl phosphate] 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei. Such analogues as 2-deoxy-a-D-Glcp-PI 25 and a-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.
|Number of pages||6|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|Publication status||Published - 1 Jan 1995|
Cottaz, S., Brimacombe, J. S., & Ferguson, M. A. J. (1995). Parasite glycoconjugates. Part 3: synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors. Journal of the Chemical Society - Perkin Transactions 1, (13), 1673-1678. http://pubs.rsc.org/en/content/articlelanding/1995/p1/p19950001673