Parasite glycoconjugates. Part 3: synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

TY - JOUR

T1 - Parasite glycoconjugates. Part 3

T2 - synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

AU - Cottaz, Sylvain

AU - Brimacombe, John S.

AU - Ferguson, Michael A. J.

N1 - Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn-2,3- bis(palmitoyloxy)propyl phosphate] 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei. Such analogues as 2-deoxy-a-D-Glcp-PI 25 and a-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.

AB - Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn-2,3- bis(palmitoyloxy)propyl phosphate] 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei. Such analogues as 2-deoxy-a-D-Glcp-PI 25 and a-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.

UR - https://www.scopus.com/pages/publications/37049071882

M3 - Article

AN - SCOPUS:37049071882

SN - 1472-7781

SP - 1673

EP - 1678

JO - Journal of the Chemical Society - Perkin Transactions 1

JF - Journal of the Chemical Society - Perkin Transactions 1

IS - 13

ER -