Parasite glycoconjugates. Part 4

chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

Andrey V. Nikolaev, Trevor J. Rutherford, Michael A. J. Ferguson, John S. Brimacombe

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    46 Citations (Scopus)

    Abstract

    The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.
    Original languageEnglish
    Pages (from-to)1977-1987
    Number of pages11
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number16
    DOIs
    Publication statusPublished - 1 Jan 1995

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    Glycoconjugates
    Diphosphates
    Disaccharides
    Oligosaccharides
    Elongation
    Phosphates
    Derivatives
    lipophosphonoglycan
    Parasites
    triphosphoric acid

    Cite this

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    title = "Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan",
    abstract = "The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.",
    author = "Nikolaev, {Andrey V.} and Rutherford, {Trevor J.} and Ferguson, {Michael A. J.} and Brimacombe, {John S.}",
    note = "Copyright 2007 Elsevier B.V., All rights reserved.",
    year = "1995",
    month = "1",
    day = "1",
    doi = "10.1039/P19950001977",
    language = "English",
    pages = "1977--1987",
    journal = "Journal of the Chemical Society - Perkin Transactions 1",
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    publisher = "Royal Society of Chemistry",
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    TY - JOUR

    T1 - Parasite glycoconjugates. Part 4

    T2 - chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

    AU - Nikolaev, Andrey V.

    AU - Rutherford, Trevor J.

    AU - Ferguson, Michael A. J.

    AU - Brimacombe, John S.

    N1 - Copyright 2007 Elsevier B.V., All rights reserved.

    PY - 1995/1/1

    Y1 - 1995/1/1

    N2 - The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.

    AB - The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.

    UR - http://www.scopus.com/inward/record.url?scp=0346100754&partnerID=8YFLogxK

    U2 - 10.1039/P19950001977

    DO - 10.1039/P19950001977

    M3 - Article

    SP - 1977

    EP - 1987

    JO - Journal of the Chemical Society - Perkin Transactions 1

    JF - Journal of the Chemical Society - Perkin Transactions 1

    SN - 0300-922X

    IS - 16

    ER -