Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

Andrey V. Nikolaev, Trevor J. Rutherford, Michael A. J. Ferguson, John S. Brimacombe

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.
    Original languageEnglish
    Pages (from-to)1977-1987
    Number of pages11
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number16
    DOIs
    Publication statusPublished - 1 Jan 1995

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