Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

Andrey V. Nikolaev; Trevor J. Rutherford; Michael A. J. Ferguson; John S. Brimacombe

doi:10.1039/P19950001977

Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

Andrey V. Nikolaev
, Trevor J. Rutherford
, Michael A. J. Ferguson
, John S. Brimacombe

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.

Original language	English
Pages (from-to)	1977-1987
Number of pages	11
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	16
DOIs	https://doi.org/10.1039/P19950001977
Publication status	Published - 1 Jan 1995

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http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-0346100754&md5=5ed02505ef4fc5e69e2c6f407c1fb876

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title = "Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan",

abstract = "The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.",

author = "Nikolaev, \{Andrey V.\} and Rutherford, \{Trevor J.\} and Ferguson, \{Michael A. J.\} and Brimacombe, \{John S.\}",

year = "1995",

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doi = "10.1039/P19950001977",

language = "English",

pages = "1977--1987",

journal = "Journal of the Chemical Society - Perkin Transactions 1",

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publisher = "Royal Society of Chemistry",

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Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan. / Nikolaev, Andrey V.; Rutherford, Trevor J.; Ferguson, Michael A. J. et al.
In: Journal of the Chemical Society - Perkin Transactions 1, No. 16, 01.01.1995, p. 1977-1987.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Parasite glycoconjugates. Part 4

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AU - Nikolaev, Andrey V.

AU - Rutherford, Trevor J.

AU - Ferguson, Michael A. J.

AU - Brimacombe, John S.

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N2 - The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.

AB - The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.

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DO - 10.1039/P19950001977

M3 - Article

AN - SCOPUS:0346100754

SN - 1472-7781

SP - 1977

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JO - Journal of the Chemical Society - Perkin Transactions 1

JF - Journal of the Chemical Society - Perkin Transactions 1

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ER -

Parasite glycoconjugates. Part 4: chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

Abstract

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