Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan

Adrian P. Higson, Yury E. Tsvetkov, Michael A. J. Ferguson, Andrei V. Nikolaev

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    Abstract

    The phosphorylated branched heptasaccharide beta-D-Galp-(1-->4)-alpha-D-Manp-(1-PO3H-6)-[beta-D-Glcp-(1-->3)]-beta-D-Galp-(1-->4)-alpha-D-Manp-(1-PO3H-6)-beta-D-Galp-(1-->4)-alpha-D-Manp-1-PO3H-O[CH2](8)CH=CH2, which is a fragment of the phosphoglycan portion of Leishmania mexicana phosphoglycan and proteophosphoglycan, has been synthesized using the thioglycoside and Helferich methods for the glycosylations and the glycosyl hydrogenphosphonate method for the successive introduction of the disaccharide phosphate and trisaccharide phosphate blocks.

    Original languageEnglish
    Pages (from-to)2587-2595
    Number of pages9
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number16
    DOIs
    Publication statusPublished - 21 Aug 1998

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