Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan

Adrian P. Higson; Yury E. Tsvetkov; Michael A. J. Ferguson; Andrei V. Nikolaev

doi:10.1039/A802747A

Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan

Adrian P. Higson
, Yury E. Tsvetkov
, Michael A. J. Ferguson
, Andrei V. Nikolaev

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The phosphorylated branched heptasaccharide beta-D-Galp-(1-->4)-alpha-D-Manp-(1-PO3H-6)-[beta-D-Glcp-(1-->3)]-beta-D-Galp-(1-->4)-alpha-D-Manp-(1-PO3H-6)-beta-D-Galp-(1-->4)-alpha-D-Manp-1-PO3H-O[CH2](8)CH=CH2, which is a fragment of the phosphoglycan portion of Leishmania mexicana phosphoglycan and proteophosphoglycan, has been synthesized using the thioglycoside and Helferich methods for the glycosylations and the glycosyl hydrogenphosphonate method for the successive introduction of the disaccharide phosphate and trisaccharide phosphate blocks.

Original language	English
Pages (from-to)	2587-2595
Number of pages	9
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	16
DOIs	https://doi.org/10.1039/A802747A
Publication status	Published - 21 Aug 1998

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Higson, A. P., Tsvetkov, Y. E., Ferguson, M. A. J., & Nikolaev, A. V. (1998). Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan. Journal of the Chemical Society - Perkin Transactions 1, (16), 2587-2595. https://doi.org/10.1039/A802747A

Higson, Adrian P. ; Tsvetkov, Yury E. ; Ferguson, Michael A. J. et al. / Parasite glycoconjugates : Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan. In: Journal of the Chemical Society - Perkin Transactions 1. 1998 ; No. 16. pp. 2587-2595.

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title = "Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan",

abstract = "The phosphorylated branched heptasaccharide beta-D-Galp-(1-->4)-alpha-D-Manp-(1-PO3H-6)-[beta-D-Glcp-(1-->3)]-beta-D-Galp-(1-->4)-alpha-D-Manp-(1-PO3H-6)-beta-D-Galp-(1-->4)-alpha-D-Manp-1-PO3H-O[CH2](8)CH=CH2, which is a fragment of the phosphoglycan portion of Leishmania mexicana phosphoglycan and proteophosphoglycan, has been synthesized using the thioglycoside and Helferich methods for the glycosylations and the glycosyl hydrogenphosphonate method for the successive introduction of the disaccharide phosphate and trisaccharide phosphate blocks.",

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Higson, AP, Tsvetkov, YE, Ferguson, MAJ & Nikolaev, AV 1998, 'Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan', Journal of the Chemical Society - Perkin Transactions 1, no. 16, pp. 2587-2595. https://doi.org/10.1039/A802747A

Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan. / Higson, Adrian P.; Tsvetkov, Yury E.; Ferguson, Michael A. J. et al.
In: Journal of the Chemical Society - Perkin Transactions 1, No. 16, 21.08.1998, p. 2587-2595.

Research output: Contribution to journal › Article › peer-review

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Higson AP, Tsvetkov YE, Ferguson MAJ, Nikolaev AV. Parasite glycoconjugates: Part 8. Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan. Journal of the Chemical Society - Perkin Transactions 1. 1998 Aug 21;(16):2587-2595. doi: 10.1039/A802747A