Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Irina A. Ivanova; Andrew J. Ross; Michael A. J. Ferguson; Andrei V. Nikolaev

doi:10.1039/A900375D

Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Irina A. Ivanova, Andrew J. Ross, Michael A. J. Ferguson, Andrei V. Nikolaev

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A set of phosphodisaccharides, substrate analogues, which will be used to study the acceptor substrate specificity of the Leishmania biosynthetic enzymes, have been synthesized using the trichloroacetimidate method for the glycosylation reactions, S(N)2 nucleophilic displacement of triflic esters for epimerization and the glycosyl hydrogenphosphonate method for phosphorylation.

Original language	English
Pages (from-to)	1743-1753
Number of pages	11
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	12
DOIs	https://doi.org/10.1039/A900375D
Publication status	Published - 21 Jun 1999

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Ivanova, I. A., Ross, A. J., Ferguson, M. A. J., & Nikolaev, A. V. (1999). Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. Journal of the Chemical Society - Perkin Transactions 1, (12), 1743-1753. https://doi.org/10.1039/A900375D

Ivanova, Irina A. ; Ross, Andrew J. ; Ferguson, Michael A. J. et al. / Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. In: Journal of the Chemical Society - Perkin Transactions 1. 1999 ; No. 12. pp. 1743-1753.

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abstract = "A set of phosphodisaccharides, substrate analogues, which will be used to study the acceptor substrate specificity of the Leishmania biosynthetic enzymes, have been synthesized using the trichloroacetimidate method for the glycosylation reactions, S(N)2 nucleophilic displacement of triflic esters for epimerization and the glycosyl hydrogenphosphonate method for phosphorylation.",

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Ivanova, IA, Ross, AJ, Ferguson, MAJ & Nikolaev, AV 1999, 'Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania', Journal of the Chemical Society - Perkin Transactions 1, no. 12, pp. 1743-1753. https://doi.org/10.1039/A900375D

Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. / Ivanova, Irina A.; Ross, Andrew J.; Ferguson, Michael A. J. et al.
In: Journal of the Chemical Society - Perkin Transactions 1, No. 12, 21.06.1999, p. 1743-1753.

Research output: Contribution to journal › Article › peer-review

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AB - A set of phosphodisaccharides, substrate analogues, which will be used to study the acceptor substrate specificity of the Leishmania biosynthetic enzymes, have been synthesized using the trichloroacetimidate method for the glycosylation reactions, S(N)2 nucleophilic displacement of triflic esters for epimerization and the glycosyl hydrogenphosphonate method for phosphorylation.

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DO - 10.1039/A900375D

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Ivanova IA, Ross AJ, Ferguson MAJ, Nikolaev AV. Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania. Journal of the Chemical Society - Perkin Transactions 1. 1999 Jun 21;(12):1743-1753. doi: 10.1039/A900375D