Parasite glycoconjugates. Part 9. Synthesis of dec-9-enyl beta-D-galactopyranosyl-(1 -> 4)-alpha-D-mannopyranosyl phosphate and its epimers at the D-galactose moiety, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Irina A. Ivanova, Andrew J. Ross, Michael A. J. Ferguson, Andrei V. Nikolaev

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    A set of phosphodisaccharides, substrate analogues, which will be used to study the acceptor substrate specificity of the Leishmania biosynthetic enzymes, have been synthesized using the trichloroacetimidate method for the glycosylation reactions, S(N)2 nucleophilic displacement of triflic esters for epimerization and the glycosyl hydrogenphosphonate method for phosphorylation.

    Original languageEnglish
    Pages (from-to)1743-1753
    Number of pages11
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number12
    Publication statusPublished - 21 Jun 1999

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