Paraspeckles

Archa H. Fox, Angus I. Lamond

    Research output: Contribution to journalArticle

    125 Citations (Scopus)

    Abstract

    Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.

    Original languageEnglish
    Article numbera000687
    Pages (from-to)-
    Number of pages14
    JournalCold spring harbor perspectives in biology
    Volume2
    Issue number7
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • MESSENGER-RNA
    • NONCODING RNAS
    • CELL-DIFFERENTIATION
    • NUCLEAR PARASPECKLES
    • SPLICING FACTOR
    • 68-KDA SUBUNIT
    • PROTEIN
    • EXPRESSION
    • DOMAIN
    • PSF

    Cite this

    Fox, Archa H. ; Lamond, Angus I. / Paraspeckles. In: Cold spring harbor perspectives in biology. 2010 ; Vol. 2, No. 7. pp. -.
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    Paraspeckles. / Fox, Archa H.; Lamond, Angus I.

    In: Cold spring harbor perspectives in biology, Vol. 2, No. 7, a000687, 07.2010, p. -.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Paraspeckles

    AU - Fox, Archa H.

    AU - Lamond, Angus I.

    PY - 2010/7

    Y1 - 2010/7

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    KW - MESSENGER-RNA

    KW - NONCODING RNAS

    KW - CELL-DIFFERENTIATION

    KW - NUCLEAR PARASPECKLES

    KW - SPLICING FACTOR

    KW - 68-KDA SUBUNIT

    KW - PROTEIN

    KW - EXPRESSION

    KW - DOMAIN

    KW - PSF

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    DO - 10.1101/cshperspect.a000687

    M3 - Article

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