Paraspeckles

Archa H. Fox, Angus I. Lamond

    Research output: Contribution to journalArticle

    144 Citations (Scopus)

    Abstract

    Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.

    Original languageEnglish
    Article numbera000687
    Pages (from-to)-
    Number of pages14
    JournalCold spring harbor perspectives in biology
    Volume2
    Issue number7
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • MESSENGER-RNA
    • NONCODING RNAS
    • CELL-DIFFERENTIATION
    • NUCLEAR PARASPECKLES
    • SPLICING FACTOR
    • 68-KDA SUBUNIT
    • PROTEIN
    • EXPRESSION
    • DOMAIN
    • PSF

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