Parenteral thiamine use in the prevention and treatment of the Wernicke-Korsakoff syndrome

Claire Mcintosh, Valerie Kippen, Fiona Hutcheson, Andrew McIntosh

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Aims and Method
A pre-/post-intervention audit of 163 case notes was conducted to assess the efficacy of printing information about the identification and treatment of the Wernicke–Korsakoff syndrome on the hospital alcohol detoxification sheet.

Results
Parenteral thiamine was indicated in 42 of 163 patients; 26 had symptoms suggestive of Wernicke's encephalopathy and 16 were at risk. The intervention increased the chance of appropriate parenteral treatment by an odds ratio of 5.9 (95% CI 1.3–27.8). Admission to a specialist alcohol unit increased the chance of appropriate treatment by an odds ratio of 7.0 (95% CI 1.52–32.25). The mean number of doses rose from 3.08 to 4.62.

Clinical Implications
A simple intervention may lead to improved treatment of patients with Wernicke–Korsakoff syndrome.
Original languageEnglish
Pages (from-to)94-97
Number of pages3
JournalPsychiatric Bulletin
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2005

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