Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins

Frank Sargent, Ben C. Berks, Tracy Palmer

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    73 Citations (Scopus)


    The twin-arginine (Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movement of folded proteins across the bacterial cytoplasmic membrane. Proteins are targeted to the Tat pathway by means of N-terminal signal peptides harbouring a distinctive twin-arginine motif. In this minireview, we describe our current knowledge of the Tat system, paying particular attention to the function of the TatA protein and to the often overlooked step of signal peptide cleavage.

    Original languageEnglish
    Pages (from-to)198-207
    Number of pages10
    JournalFEMS Microbiology Letters
    Issue number2
    Publication statusPublished - 2006

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