Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins

TY - JOUR

T1 - Pathfinders and trailblazers

T2 - a prokaryotic targeting system for transport of folded proteins

AU - Sargent, Frank

AU - Berks, Ben C.

AU - Palmer, Tracy

PY - 2006

Y1 - 2006

N2 - The twin-arginine (Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movement of folded proteins across the bacterial cytoplasmic membrane. Proteins are targeted to the Tat pathway by means of N-terminal signal peptides harbouring a distinctive twin-arginine motif. In this minireview, we describe our current knowledge of the Tat system, paying particular attention to the function of the TatA protein and to the often overlooked step of signal peptide cleavage.

AB - The twin-arginine (Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movement of folded proteins across the bacterial cytoplasmic membrane. Proteins are targeted to the Tat pathway by means of N-terminal signal peptides harbouring a distinctive twin-arginine motif. In this minireview, we describe our current knowledge of the Tat system, paying particular attention to the function of the TatA protein and to the often overlooked step of signal peptide cleavage.

U2 - 10.1111/j.1574-6968.2005.00049.x

DO - 10.1111/j.1574-6968.2005.00049.x

M3 - Article

C2 - 16445746

SN - 0378-1097

VL - 254

SP - 198

EP - 207

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 2

ER -