Pathology and histology of the oesophagus and stomach

Yvonne L. Woods, Frank A. Carey

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The presenting symptoms of dysphagia and dyspepsia can be caused by gastro-oesophageal reflux disease, malignancy or, less commonly, disorders of dysfunctional motility, such as achalasia. Most neoplasms of the oesophagus and stomach are epithelial in nature. Benign epithelial neoplasms usually take the form of polypoid lesions, such as oesophageal squamous papillomas, gastric adenomas, hyperplastic and fundic gland polyps. Malignant epithelial neoplasms of the oesophagus are divided into squamous cell carcinoma and adenocarcinoma, whereas malignant gastric neoplasms are predominantly adenocarcinomas. Each tends to develop in the context of dysplastic epithelial changes. Gastric carcinomas and lymphomas are associated with Helicobacter pylori infection. Stromal tumours of the stomach are important in that they have a distinctive molecular pathology and linked targeted therapy. This educational article provides an overview of the incidences, aetiologies and histological features of some of the most common mechanical, inflammatory and neoplastic pathologies encountered in the oesophagus and stomach. The emphasis is on clinical application.

    Original languageEnglish
    Pages (from-to)612-618
    Number of pages7
    JournalSurgery (Oxford)
    Volume35
    Issue number11
    Early online date20 Oct 2017
    DOIs
    Publication statusPublished - Nov 2017

    Keywords

    • Achalasia
    • Adenocarcinoma
    • Atresia
    • Barrett's oesophagus
    • Gastrointestinal stromal tumour
    • Helicobacter pylori gastritis
    • Marginal zone lymphoma
    • Oesophagus
    • Squamous cell carcinoma
    • Stomach

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