Pattern of brain metastatic disease according to HER-2 and ER receptor status in breast cancer patients

K. Lekanidi, A. L. Evans, J. Shah, T. Jaspan, Lee Baker, A. J. Evans

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)


    Aims: To document the type, location, extent, and complications of brain metastases in patients with breast cancer and identify associations with oestrogen receptor (ER) negative and human epidermal growth factor receptor 2 (HER-2) receptor expression. Materials and methods: Breast cancer patients with known brain metastases were included in this retrospective study, if cross-sectional imaging of the brain [computed tomography (CT)] was available to review and HER-2 and ER status was known. Two neuroradiologists, who were blinded to the receptor status, separately and for each patient, documented on a proforma the location, number, and dimensions of the deposits and the presence or absence of hydrocephalus. Adjudication was sought where there was discrepancy between the two reports. ER status, HER-2 receptor status, and patient age were also documented. The results were analysed using two-sided Fisher's exact tests with Lancaster's mid-P correction and associations were sought between the tumour characteristics and the pattern of brain disease. Results: Sixty patients were included in the study. There was an association between young age (
    Original languageEnglish
    Pages (from-to)1070-1073
    Number of pages4
    JournalClinical Radiology
    Issue number10
    Early online date1 Jul 2013
    Publication statusPublished - Oct 2013


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