TY - JOUR
T1 - Pattern of brain metastatic disease according to HER-2 and ER receptor status in breast cancer patients
AU - Lekanidi, K.
AU - Evans, A. L.
AU - Shah, J.
AU - Jaspan, T.
AU - Baker, Lee
AU - Evans, A. J.
PY - 2013/10
Y1 - 2013/10
N2 - Aims: To document the type, location, extent, and complications of brain metastases in patients with breast cancer and identify associations with oestrogen receptor (ER) negative and human epidermal growth factor receptor 2 (HER-2) receptor expression. Materials and methods: Breast cancer patients with known brain metastases were included in this retrospective study, if cross-sectional imaging of the brain [computed tomography (CT)] was available to review and HER-2 and ER status was known. Two neuroradiologists, who were blinded to the receptor status, separately and for each patient, documented on a proforma the location, number, and dimensions of the deposits and the presence or absence of hydrocephalus. Adjudication was sought where there was discrepancy between the two reports. ER status, HER-2 receptor status, and patient age were also documented. The results were analysed using two-sided Fisher's exact tests with Lancaster's mid-P correction and associations were sought between the tumour characteristics and the pattern of brain disease. Results: Sixty patients were included in the study. There was an association between young age (
AB - Aims: To document the type, location, extent, and complications of brain metastases in patients with breast cancer and identify associations with oestrogen receptor (ER) negative and human epidermal growth factor receptor 2 (HER-2) receptor expression. Materials and methods: Breast cancer patients with known brain metastases were included in this retrospective study, if cross-sectional imaging of the brain [computed tomography (CT)] was available to review and HER-2 and ER status was known. Two neuroradiologists, who were blinded to the receptor status, separately and for each patient, documented on a proforma the location, number, and dimensions of the deposits and the presence or absence of hydrocephalus. Adjudication was sought where there was discrepancy between the two reports. ER status, HER-2 receptor status, and patient age were also documented. The results were analysed using two-sided Fisher's exact tests with Lancaster's mid-P correction and associations were sought between the tumour characteristics and the pattern of brain disease. Results: Sixty patients were included in the study. There was an association between young age (
UR - http://www.scopus.com/inward/record.url?scp=84879447472&partnerID=8YFLogxK
U2 - 10.1016/j.crad.2013.05.091
DO - 10.1016/j.crad.2013.05.091
M3 - Article
C2 - 23827085
SN - 0009-9260
VL - 68
SP - 1070
EP - 1073
JO - Clinical Radiology
JF - Clinical Radiology
IS - 10
ER -
