Pattern of brain metastatic disease according to HER-2 and ER receptor status in breast cancer patients

TY - JOUR

T1 - Pattern of brain metastatic disease according to HER-2 and ER receptor status in breast cancer patients

AU - Lekanidi, K.

AU - Evans, A. L.

AU - Shah, J.

AU - Jaspan, T.

AU - Baker, Lee

AU - Evans, A. J.

PY - 2013/10

Y1 - 2013/10

N2 - Aims: To document the type, location, extent, and complications of brain metastases in patients with breast cancer and identify associations with oestrogen receptor (ER) negative and human epidermal growth factor receptor 2 (HER-2) receptor expression. Materials and methods: Breast cancer patients with known brain metastases were included in this retrospective study, if cross-sectional imaging of the brain [computed tomography (CT)] was available to review and HER-2 and ER status was known. Two neuroradiologists, who were blinded to the receptor status, separately and for each patient, documented on a proforma the location, number, and dimensions of the deposits and the presence or absence of hydrocephalus. Adjudication was sought where there was discrepancy between the two reports. ER status, HER-2 receptor status, and patient age were also documented. The results were analysed using two-sided Fisher's exact tests with Lancaster's mid-P correction and associations were sought between the tumour characteristics and the pattern of brain disease. Results: Sixty patients were included in the study. There was an association between young age (

AB - Aims: To document the type, location, extent, and complications of brain metastases in patients with breast cancer and identify associations with oestrogen receptor (ER) negative and human epidermal growth factor receptor 2 (HER-2) receptor expression. Materials and methods: Breast cancer patients with known brain metastases were included in this retrospective study, if cross-sectional imaging of the brain [computed tomography (CT)] was available to review and HER-2 and ER status was known. Two neuroradiologists, who were blinded to the receptor status, separately and for each patient, documented on a proforma the location, number, and dimensions of the deposits and the presence or absence of hydrocephalus. Adjudication was sought where there was discrepancy between the two reports. ER status, HER-2 receptor status, and patient age were also documented. The results were analysed using two-sided Fisher's exact tests with Lancaster's mid-P correction and associations were sought between the tumour characteristics and the pattern of brain disease. Results: Sixty patients were included in the study. There was an association between young age (

UR - https://www.scopus.com/pages/publications/84883462458

U2 - 10.1016/j.crad.2013.05.091

DO - 10.1016/j.crad.2013.05.091

M3 - Article

C2 - 23827085

SN - 0009-9260

VL - 68

SP - 1070

EP - 1073

JO - Clinical Radiology

JF - Clinical Radiology

IS - 10

ER -