Patterns, receptors and signals: regulation of phagosome maturation

Anne-Marie Pauwels, Matthias Trost, Rudi Beyaert, Eik Hoffmann (Lead / Corresponding author)

Research output: Contribution to journalReview article

75 Citations (Scopus)
158 Downloads (Pure)

Abstract

Recognition of microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments, a process called phagosome maturation, which leads to the degradation of the phagosomal content. However, many phagocytic cells also act as antigen-presenting cells and must balance degradation and peptide preservation. Emerging evidence indicates that receptor engagement by phagosomal cargo, as well as inflammatory mediators and cellular activation affect many aspects of phagosome maturation. Unsurprisingly, pathogens have developed strategies to hijack this machinery thereby interfering with host immunity. Here, we highlight progress in this field, summarize findings on the impact of immune signals and discuss consequences on pathogen elimination.
Original languageEnglish
Pages (from-to)407-422
Number of pages16
JournalTrends in Immunology
Volume28
Issue number6
Early online date14 Apr 2017
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Phagocytosis
  • Phagosome maturation
  • Inflammation
  • Immune response
  • Antigen presentation
  • Host-pathogen interation

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