PC12 Interaction with Magnetic Nanotubes: Effects on Viability, Cell Differentiation and Cell Translocation Induced by a Magnetic Field

Orazio Vittorio, Vittoria Raffa, Cristina Riggio, Andrea Pietrabissa, Alfred Cuschieri

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    5 Citations (Scopus)

    Abstract

    In this paper we used Multi Wall Carbon Nanotubes (MWCNTs) containing 3% of residuals and impurities of Fe, Al, and Zn. MWCNTs, by virtue of Fe at their tips, are able to respond to the effects of external magnetic fields. We demonstrated that MWCNTs interact with PC12 cells without compromising their viability and differentiation with outgrowth of neurites. We also document that when exposed to a magnetic field, both undifferentiated and differentiated PC12 cells cultured in CNT-containing medium solution are able to move towards the magnetic source.

    Original languageEnglish
    Pages (from-to)337-344
    Number of pages8
    JournalCurrent Nanoscience
    Volume7
    Issue number3
    Publication statusPublished - Jun 2011

    Keywords

    • Nanoparticles
    • magnetic materials
    • cell displacement
    • neuronal differentiation
    • WALLED CARBON NANOTUBES
    • NEURONAL GROWTH
    • IN-VITRO
    • PEPTIDES

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