Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

D. Prabhu; R. S. Dawe; K. Mponda

doi:10.1111/phpp.12659

Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

D. Prabhu, R. S. Dawe (Lead / Corresponding author), K. Mponda

Molecular and Clinical Medicine

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

124 Downloads (Pure)

Abstract

Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

Original language	English
Pages (from-to)	99-104
Number of pages	6
Journal	Photodermatology, Photoimmunology & Photomedicine
Volume	37
Issue number	2
Early online date	20 Jan 2021
DOIs	https://doi.org/10.1111/phpp.12659
Publication status	Published - 2 Feb 2021

Keywords

Hartnup's disease
carcinoid syndrome
drug-induced pellagra
isoniazid
niacin
nutrition
pellagra
photosensitivity
tryptophan

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Radiology Nuclear Medicine and imaging
Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/phpp.12659

Author Accepted ManuscriptAccepted author manuscript, 7.85 MB

Cite this

@article{e1ac03c05cd94f7586221c9506fff801,

title = "Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra",

abstract = "Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.",

keywords = "Hartnup's disease, carcinoid syndrome, drug-induced pellagra, isoniazid, niacin, nutrition, pellagra, photosensitivity, tryptophan",

author = "D. Prabhu and Dawe, {R. S.} and K. Mponda",

year = "2021",

month = feb,

day = "2",

doi = "10.1111/phpp.12659",

language = "English",

volume = "37",

pages = "99--104",

journal = "Photodermatology, Photoimmunology & Photomedicine",

issn = "0905-4383",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

AU - Prabhu, D.

AU - Dawe, R. S.

AU - Mponda, K.

PY - 2021/2/2

Y1 - 2021/2/2

N2 - Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

AB - Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

KW - Hartnup's disease

KW - carcinoid syndrome

KW - drug-induced pellagra

KW - isoniazid

KW - niacin

KW - nutrition

KW - pellagra

KW - photosensitivity

KW - tryptophan

UR - http://www.scopus.com/inward/record.url?scp=85100089831&partnerID=8YFLogxK

U2 - 10.1111/phpp.12659

DO - 10.1111/phpp.12659

M3 - Review article

C2 - 33471377

SN - 0905-4383

VL - 37

SP - 99

EP - 104

JO - Photodermatology, Photoimmunology & Photomedicine

JF - Photodermatology, Photoimmunology & Photomedicine

IS - 2

ER -

Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this