Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

D. Prabhu, R. S. Dawe (Lead / Corresponding author), K. Mponda

Research output: Contribution to journal › Review article › peer-review

Abstract

Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

Original languageEnglish
JournalPhotodermatology, Photoimmunology & Photomedicine
DOIs
Publication statusE-pub ahead of print - 20 Jan 2021

Keywords

  • carcinoid syndrome
  • drug‐induced pellagra
  • Hartnup’s disease
  • isoniazid
  • niacin
  • nutrition
  • pellagra
  • photosensitivity
  • tryptophan

Access to Document

    Embargoed Document

  • Author Accepted Manuscript

    Accepted author manuscript, 7.85 MB

    Embargo ends: 20/01/22

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