Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

D. Prabhu, R. S. Dawe (Lead / Corresponding author), K. Mponda

    Research output: Contribution to journalReview articlepeer-review

    28 Citations (Scopus)
    328 Downloads (Pure)

    Abstract

    Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

    Original languageEnglish
    Pages (from-to)99-104
    Number of pages6
    JournalPhotodermatology, Photoimmunology & Photomedicine
    Volume37
    Issue number2
    Early online date20 Jan 2021
    DOIs
    Publication statusPublished - 2 Feb 2021

    Keywords

    • Hartnup's disease
    • carcinoid syndrome
    • drug-induced pellagra
    • isoniazid
    • niacin
    • nutrition
    • pellagra
    • photosensitivity
    • tryptophan

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Radiology Nuclear Medicine and imaging
    • Dermatology

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