Pellagra a review exploring causes and mechanisms, including isoniazid induced pellagra

D. Prabhu, R. S. Dawe (Lead / Corresponding author), K. Mponda

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's- dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalPhotodermatology, Photoimmunology & Photomedicine
Volume37
Issue number2
Early online date20 Jan 2021
DOIs
Publication statusPublished - 2 Feb 2021

Keywords

  • Hartnup's disease
  • carcinoid syndrome
  • drug-induced pellagra
  • isoniazid
  • niacin
  • nutrition
  • pellagra
  • photosensitivity
  • tryptophan

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