Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Huda Alkhadar, Michaelina Macluskey (Lead / Corresponding author), Sharon White, Ian Ellis

Research output: Contribution to journalArticle

9 Downloads (Pure)

Abstract

Background

The objective of this study was to characterise the incidence and prognostic correlation of perineural invasion (PNI) in oral squamous cell carcinoma and determine whether nerve growth factor and its receptor tyrosine Kinase A expression could be used as biological markers for PNI.


Methods

A retrospective review of pathology reports of 430 patients with oral squamous cell carcinoma who were treated from 1992 to 2014 in Tayside, Scotland, was carried out. The expression of nerve growth factor and tyrosine kinase A was assessed with immunohistochemistry in 132 tissue sections of oral squamous cell carcinoma.


Results

Perineural invasion was identified in 17.4% of oral squamous cell carcinomas. High expression of nerve growth factor and tyrosine kinase A was seen in 84% and 92% of oral squamous cell carcinoma, respectively. Tumours with PNI expressed nerve growth factor and tyrosine kinase A with a greater frequency than tumours without PNI. PNI and high expression of nerve growth factor were significantly associated with pain. PNI was significantly associated with stage IV tumours and poor disease‐specific survival.


Conclusions

A higher level of expression of nerve growth factor and tyrosine kinase A may predict PNI and therefore may be considered as biological markers for PNI in oral squamous cell carcinoma. PNI and nerve growth factor overexpression may contribute to the pain generation in oral cancer patients. PNI and nerve growth factor expression can predict the aggressiveness and prognosis of oral squamous cell carcinoma patients.

Original languageEnglish
Number of pages10
JournalJournal of Oral Pathology and Medicine
Early online date12 Jun 2020
DOIs
Publication statusE-pub ahead of print - 12 Jun 2020

Keywords

  • Perineural Invasion
  • Oral Squamous Cell Carcinoma
  • Nerve Growth Factor
  • Tyrosine Kinase A
  • perineural invasion
  • nerve growth factor
  • tyrosine kinase A
  • oral squamous cell carcinoma

Fingerprint Dive into the research topics of 'Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight'. Together they form a unique fingerprint.

  • Student Theses

    Perineural Invasion in Oral Squamous Cell Carcinoma and Salivary Gland Malignancies: Incidence, Prognostic Impact and Molecular Insight

    Author: Alkhadar, H., 2020

    Supervisor: Macluskey, M. (Supervisor), Ellis, I. (Supervisor) & White, S. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Cite this