Single clouds of cavitation bubbles, driven by 254kHz focused ultrasound at pressure amplitudes in the range of 0.48-1.22MPa, have been observed via high-speed shadowgraphic imaging at 1×10(6) frames per second. Clouds underwent repetitive growth, oscillation and collapse (GOC) cycles, with shock-waves emitted periodically at the instant of collapse during each cycle. The frequency of cloud collapse, and coincident shock-emission, was primarily dependent on the intensity of the focused ultrasound driving the activity. The lowest peak-to-peak pressure amplitude of 0.48MPa generated shock-waves with an average period of 7.9±0.5µs, corresponding to a frequency of f0/2, half-harmonic to the fundamental driving. Increasing the intensity gave rise to GOC cycles and shock-emission periods of 11.8±0.3, 15.8±0.3, 19.8±0.2µs, at pressure amplitudes of 0.64, 0.92 and 1.22MPa, corresponding to the higher-order subharmonics of f0/3, f0/4 and f0/5, respectively. Parallel passive acoustic detection, filtered for the fundamental driving, revealed features that correlated temporally to the shock-emissions observed via high-speed imaging, p(two-tailed) 200µm diameter, at maximum inflation), that developed under insonations of peak-to-peak pressure amplitudes >1.0MPa, emitted shock-waves with two or more fronts suggesting non-uniform collapse of the cloud. The observations indicate that periodic shock-emissions from acoustically driven cavitation clouds provide a source for the cavitation subharmonic signal, and that shock structure may be used to study intra-cloud dynamics at sub-microsecond timescales.