Abstract
With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections.
Original language | English |
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Pages (from-to) | 666-667 |
Number of pages | 2 |
Journal | Thorax |
Volume | 72 |
Issue number | 7 |
Early online date | 6 Mar 2017 |
DOIs | |
Publication status | Published - 16 Jun 2017 |
Keywords
- Bacterial Infection
- Cystic Fibrosis
- Respiratory Infection
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine