Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa

Elaine M. Waters, Daniel R. Neill, Basak Kaman, Jaspreet S. Sahota, Martha R.J. Clokie, Craig Winstanley, Aras Kadioglu

Research output: Contribution to journalLetterpeer-review

156 Citations (Scopus)
124 Downloads (Pure)

Abstract

With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections.

Original languageEnglish
Pages (from-to)666-667
Number of pages2
JournalThorax
Volume72
Issue number7
Early online date6 Mar 2017
DOIs
Publication statusPublished - 16 Jun 2017

Keywords

  • Bacterial Infection
  • Cystic Fibrosis
  • Respiratory Infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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