Phagosome Neutrality in Host Defense

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)


    Activation of proteases in the phagosomes of neutrophils occurs by neutralization of the phagosomal pH by NADPH oxidase. In this issue, Savina et al. (2006) show that dendritic cell phagosomes also recruit NADPH oxidase but with different results. Here, the neutralization of phagosomal pH reduces protease activity, which preserves antigens for crosspresentation on class I MHC molecules.

    Original languageEnglish
    Pages (from-to)17-19
    Number of pages3
    Issue number1
    Publication statusPublished - 14 Jul 2006

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)


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