Abstract
Activation of proteases in the phagosomes of neutrophils occurs by neutralization of the phagosomal pH by NADPH oxidase. In this issue, Savina et al. (2006) show that dendritic cell phagosomes also recruit NADPH oxidase but with different results. Here, the neutralization of phagosomal pH reduces protease activity, which preserves antigens for crosspresentation on class I MHC molecules.
Original language | English |
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Pages (from-to) | 17-19 |
Number of pages | 3 |
Journal | Cell |
Volume | 126 |
Issue number | 1 |
DOIs | |
Publication status | Published - 14 Jul 2006 |
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology